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Publications - Project 3

Publications - Project 3

Sex-specific acute and chronic neurotoxicity of acute diisopropylfluorophosphate (DFP)-intoxication in juvenile Sprague-Dawley rats
González EA, Calsbeek JJ, Tsai Y-H, Tang M-Y, Andrew P, Vu J, Berg EL, Saito NH, Harvey DJ, Supasai S, Gurkoff GG, Silverman JL, Lein PJ
Current Research in Toxicology. 2021. 2:341-356. In publication.

Persistent neuropathology and behavioral deficits in a mouse model of status epilepticus induced by acute intoxication with diisopropylfluorophosphate
Calsbeek JJ, González EA, Bruun DA, Guignet MA, Copping N, Dawson ME, Yu AJ, MacMahon JA, Saito NH, Harvey DJ, Silverman JL, Lein PJ.
Neurotoxicology. 2021 Sep 9:S0161-813X(21)00113-3. PMID: 34509511

The efficacy of γ-aminobutyric acid type A receptor (GABA AR) subtype-selective positive allosteric modulators in blocking tetramethylenedisulfotetramine (TETS)-induced seizure-like behavior in larval zebrafish with minimal sedation
Mundy PC, Pressly B, Carty DR, Yaghoobi B, Wulff H, Lein PJ.
Toxicol Appl Pharmacol. 2021 Sep 1;426:115643. PMID: 34265354

Strain differences in the extent of brain injury in mice after tetramethylenedisulfotetramine-induced status epilepticus
Calsbeek JJ, Gonzalez EA, Boosalis CA, Zolkowska D, Bruun DA, Rowland DJ, Saito NH, Harvey DJ, Chaudhari AJ, Rogawski MA, Garbow JR, Lein PJ
NeuroToxicology. 2021 Aug 31; 87:43-50. PMID: 34478772

Neuroinflammation as a therapeutic target for mitigating the long-term consequences of acute organophosphate intoxication
Andrew PM and Lein PJ
Front Pharmacol. 2021 May 12;12:674325. PMCID: PMC8153682

Mechanisms of organophosphate neurotoxicity
Tsai Y-H and Lein PJ
Current Opinion in Tox, 2021 April; 26:49-60. 

Colocalization of fluorescent signals using deep learning with Manders overlapping coefficient
Dou Y,
Tsai Y-H, Liu CC, Hobson BA, Lein PJ
SPIE Proceedings. 2021 Feb 21;11596;Medical Imaging 2021: Image Processing; 115963C

Acute administration of diazepam or midazolam minimally alters long-term neuropathological effects in the rat brain following acute intoxication with diisopropylfluorophosphate.
Supasai S, González EA, Rowland DJ, Hobson B, Bruun DA, Guignet MA, Soares S, Singh V, Wulff H, Saito N, Harvey DJ, Lein PJ.
Eur J Pharmacol. 2020 Nov 5;886:173538. PMID: 32898549; PMCID: PMC7572820 (available on 2021-11-05)

Allopregnanolone and perampanel as adjuncts to midazolam for treating diisopropylfluorophosphate-induced status epilepticus in rats
Dhir A, Bruun DA, Guignet M, Tsai Y-H, González E, Calsbeek J, Vu J, Saito N, Tancredi DJ, Harvey DJ, Lein PJ, Rogawski MA
Ann NY Acad Sci 2020 Sep 11, 1-23. PMID: 32915470; PMCID: PMC7756871

The chemical convulsant diisopropylfluorophosphate (DFP) causes persistent neuropathology in adult male rats independent of seizure activity
González EA, Rindy AC, Guignet MA, Calsbeek JJ, Bruun DA, Dhir A, Andrew P, Saito N, Rowland DJ, Harvey DJ, Rogawski MA, Lein PJ .
Archives In Toxicolology 2020 June;94:2149-2162. PMID: 32303805; PMCID: PMC7305973 (available on 2021-06-01)

Persistent behavioral deficits, neuroinflammation and oxidative stress in a rat model of acute organophosphate intoxication
Guignet M, Dhakal K, Flannery BM, Hobson BA, Zolkowska D, Dhir A, Bruun DA, Li S, Harvey DJ, Silverman JL, Rogawski MA, Lein PJ
Neurobiol Dis. 2020 Jan;133:104431. PMID: 30905768; PMCID: PMC6754818

Lipidomes of brain from rats acutely intoxicated with diisopropylfluorophosphate identifies potential therapeutic targets
Yang J, Bruun DA, Wang C, Wan D, McReynolds CB, Phu K, Inceoglu B, Lein PJ, Hammock BD
Toxicol Appl Pharmacol. 2019 Nov 1;382:114749. PMID: 31521729; PMCID: PMC6957308

Pretreatment with pyridostigmine bromide has no effect on seizure behavior or 24 hour survival in the rat model of acute diisopropylfluorophosphate intoxication
Bruun DA, Guignet M, Harvey DJ, Lein PJ
Neurotoxicology. 2019 Jul;73:81-84 PMID: 30853371; PMCID: PMC66344995

TSPO PET using [18F]PBR111 reveals persistent neuroinflammation following acute diisopropylfluorophosphate intoxication in the rat
Hobson BA, Rowland DJ, Siso S, Guignet MA, Harmany ZT, Bandara S, Saito N, Harvey DJ, Bruun DA, Garbow JR, Chaudhari AF, Lein PJ
Toxicol Sci. 2019: 170(2):330-344. PMC6657665; PMCID: PMC6657665

A magnetic resonance imaging study of early brain injury in a rat model of acute DFP intoxication
Hobson BA, Rowland DJ, Supasai S, Harvey DJ, Lein PJ, Garbow JR
Neurotoxicology. 2018 May;66:170-178.  PMID: 29183789; PMCID: PMC5940565

Editor's Highlight: Spatiotemporal Progression and Remission of Lesions in the Rat Brain Following Acute Intoxication With Diisopropylfluorophosphate
Sisó S, Hobson BA, Harvey DJ, Bruun DA, Rowland DJ, Garbow JR, Lein PJ
Toxicol Sci. 2017 Jun 1;157(2):330-341. PMID: 28329845

From the Cover: MagneticResonance Imaging Reveals Progressive Brain Injury in Rats Acutely Intoxicated With Diisopropylfluorophosphate
Hobson BA, Sisó S, Rowland DJ, Harvey DJ, Bruun DA, Garbow JR, Lein PJ
Toxicol Sci. 2017 Jun 1;157(2):342-353. PMID: 28329842

Persistent neuroinflammation and cognitive impairment in a rat model of acute diisopropylfluorophosphate intoxication
Flannery BM, Bruun DA, Rowland DJ, Banks CN, Austin AT, Kukis DL, Li Y, Ford BD, Tancredi DJ, Silverman JL, Cherry SR, Lein PJ
J Neuroinflammation. 2016 Oct 12;13(1):267. PMID: 27733171 

Combined treatment with diazepam and allopregnanolone reverses tetramethylenedisulfotetramine (TETS)-induced calcium dysregulation in cultured neurons and protects TETS-intoxicated mice against lethal seizures
Bruun DA, Cao Z, Inceoglu B, Vito ST, Austin AT, Hulsizer S, Hammock BD, Tancredi DJ, Rogawski MA, Pessah IN, Lein PJ
Neuropharmacology. 2015 Aug;95:332-42. PMID: 25882826

Behavioral assessment of NIH Swiss mice acutely intoxicated with tetramethylenedisulfotetramine
Flannery BM, Silverman JL, Bruun DA, Puhger KR, McCoy MR, Hammock BD, Crawley JN, Lein PJ.
Neurotoxicol Teratol. 2015 Jan-Feb;47:36-45. PMID: 25446016