Isaac N. Pessah has 30 years experience working in the field of molecular and cellular neuropharmacology and neurotoxicology. His research has focused on defining the molecular mechanisms by which neuromodulators, neurotoxicants, and natural products influence Ca2+ signaling pathways in excitable cells (muscle and neurons) and how such changes influence normal development, excitability and pathological excitotoxicity.
People - Project 1
The general focus of my research is the calcium signaling in skeletal muscle and brain cells. The primary focus is the function and pharmacology of calcium release mechanisms in sarcoplasmic/endoplasmic reticulum as well as calcium entry mechanisms in plasma membrane in both physiological and pathophysiological conditions.