Acute intoxication with chemical threat agent diisopropylfluorophosphate causes persistent neuropathology via seizure-independent mechanisms.
González EA, Rindy AC, Guignet MA, Bruun DA, Rowland DJ, Harvey DJ, Lein PJ
Epilepsia (under review)

The trials and tribulations of structure assisted design of KCa channel activators.
Shim H, Brown BM, Singh L, Singh V, Fettinger JC, Yarov-Yarovoy V, Wulff H
Front Pharmacol (under review)

Guignet M, Lein PJ
In: Advances in Neurotoxicology: Role of Inflammation in Environmental Neurotoxicity, volume 3 (Edited by M Aschner, LG Costa), Academic Press, Cambridge, MA, pp. 35-79. 2019

The use of percent change in RR interval for data exclusion in analyzing 24 hour time domain heart rate variability in rats.
Karey E, Pan S, Morris A, Bruun DA, Lein PJ, Chen CY
Front. Physiol., 06 June 2019

Persistent neuroinflammation following acute DFP intoxicated revealed by TSPO PET Using [18F]PBR111.
Hobson BA, Rowland DJ, Siso S, Harmany ZT, Bandara S, Harvey DJ, Bruun DA, Garbow JR, Chaudari AF, Lein PJ
Toxicol Sci. (under review)

Differential seizure susceptibility to GABAA receptor-targeting chemical threat agents in larval zebrafish.
Bandara SB, Carty DR, Miller GW, Feldman DH, Lein PJ
Toxicol Sci. (under review)

Persistent behavioral deficits, neuroinflammation and oxidative stress in a rat model of diisopropylfluorophosphate (DFP)-induced status epilepticus.
Guignet M, Dhakal K, Flannery BM, Hobson BA, Zolkowska D, Dhir A, Bruun DA, Li S, Harvey DJ, Silverman JL, Rogawski MA, Lein PJ
Acta Neuropathologica. (in press)
Neurobiol Dis. NIHMS1525963

Antibodies and venom peptides: new modalities for ion channels.
Wulff H, Christophersen P, Colussi P, Chandy KG, Yarov-Yarovoy V.
Nat Rev Drug Discov.2019 May;18(5):339-357. doi: 10.1038/s41573-019-0013-8.
PubMed PMID: 30728472; PMCID: PMC6499689

Pretreatment with pyridostigmine bromide has no effect on seizure behavior or 24 hour survival in the rat model of acute diisopropylfluorophosphate intoxication
Bruun DA, Guignet M, Harvey DJ, Lein PJ
Neurotoxicology. 2019 Mar 7;73:81-84. doi: 10.1016/j.neuro.2019.03.001. [Epub ahead of print]
PubMed PMID: 30853371

The pharmacokinetics of ketamine following intramuscular injection to F344 rats.
Moeller B, Espelien B, Weber W, Kuehl P, Doyle-Eisele M, Garner CE, McDonald JD, Garcia E, Raulli R, Laney J.
Drug Test Anal.2019 Jan;11(1):68-76. doi: 10.1002/dta.2468. Epub 2018 Aug 14.
PubMed PMID: 30027605; PMCID: .PMC6538562

Bifenthrin causes transcriptomic alterations in mTOR and ryanodine receptor-dependent signaling and delayed hyperactivity in developing
zebrafish (Danio rerio).
Frank DF, Miller GW, Harvey DJ, Brander SM, Geist J, Connon RE, Lein PJ.
Aquat Toxicol. 2018 Jul;200:50-61. doi: 10.1016/j.aquatox.2018.04.003. Epub 2018 Apr 18.
PMID: 29727771

A New Conjugation Method Used for the Development of an Immunoassay for the Detection of Amanitin, a Deadly
Mushroom Toxin.
Bever CS, Barnych B, Hnasko R, Cheng LW, Stanker LH.
Toxins. 2018 June 28;10(7).
PubMed PMID: 29958410; PubMed Central PMCID: PMC6070930.

A Microfluidic Platform to Study Astrocyte Adhesion on Nanoporous Gold Thin Films.
Hampe AE, Li Z, Sethi S, Lein PJ, Seker E.
Nanomaterials (Basel, Switzerland). 2018 June 21;8(7).
PubMed PMID: 29933551; PubMed Central PMCID: PMC6070884.

Determination of minimal steady-state plasma level of diazepam causing seizure threshold elevation in rats.
Dhir A, Rogawski MA
Epilepsia.2018 May;59(5):935-944. doi: 10.1111/epi.14069. Epub 2018 Apr 6.
PubMed PMID: 29682729; PMCID: PMC5934328

A magnetic resonance imaging study of early brain injury in a rat model of acute DFP intoxication.
Hobson BA, Rowland DJ, Supasai S, Harvey DJ, Lein PJ, Garbow JR.
Neurotoxicology. 2018 May;66:170-178. doi: 10.1016/j.neuro.2017.11.009. Epub 2017 Nov 26.
PubMed PMID: 29183789; PMCID: PMC5940565

Soluble epoxide hydrolase inhibition decreases reperfusion injury after focal cerebral ischemia.
Tu R, Armstrong J, Lee KSS, Hammock BD, Sapirstein A, Koehler RC.
Scientific reports. 2018 March 27;8(1):5279.
PubMed PMID: 29588470; PubMed Central PMCID: PMC5869703

COX-2/sEH Dual Inhibitor PTUPB Potentiates the Antitumor Efficacy of Cisplatin.
Wang F, Zhang H, Ma AH, Yu W, Zimmermann M, Yang J, Hwang SH, Zhu D, Lin TY, Malfatti M,
Turteltaub KW, Henderson PT, Airhart S, Hammock BD, Yuan J, de Vere White RW, Pan CX
Molecular cancer therapeutics. 2018 February;17(2):474-483.
PubMed PMID: 29284644; PubMed Central PMCID: PMC5824635.

GABAA receptor subtype selectivity of the proconvulsant rodenticide TETS.
Pressly B, Nguyen HM, Wulff H.
Arch Toxicol. 2018 Feb;92(2):833-844. doi: 10.1007/s00204-017-2089-4. Epub 2017 Oct 16.
PubMed PMID: 29038840

Structural Determinants for the Selectivity of the Positive KCa3.1 Gating Modulator 5-Methylnaphtho[2,1-d]oxazol-2-amine (SKA-121).
Brown BM, Shim H, Zhang M, Yarov-Yarovoy V, Wulff H.
Mol Pharmacol. 2017 Oct;92(4):469-480. doi: 10.1124/mol.117.109421. Epub 2017 Jul 31.
PMID: 28760780

Rapid Throughput Analysis of GABAAReceptor Subtype Modulators and Blockers Using DiSBAC1(3) Membrane Potential Red Dye.
Nik AM, Pressly B, Singh V, Antrobus S, Hulsizer S, Rogawski MA, Wulff H, Pessah IN.
Mol Pharmacol. 2017 Jul;92(1):88-99. doi: 10.1124/mol.117.108563. Epub 2017 Apr 20.
PMID: 28428226

Editor's Highlight: Spatiotemporal Progression and Remission of Lesions in the Rat Brain Following Acute Intoxication With
Sisó S, Hobson BA, Harvey DJ, Bruun DA, Rowland DJ, Garbow JR, Lein PJ.
Toxicol Sci. 2017 Jun 1;157(2):330-341. doi: 10.1093/toxsci/kfx048.
PMID: 28329845

From the Cover: MagneticResonance Imaging Reveals Progressive Brain Injury in Rats Acutely Intoxicated With Diisopropylfluorophosphate.
Hobson BA, Sisó S, Rowland DJ, Harvey DJ, Bruun DA, Garbow JR, Lein PJ.
Toxicol Sci. 2017 Jun 1;157(2):342-353. doi: 10.1093/toxsci/kfx049.
PMID: 28329842

Hydroxy-fipronil is a new urinary biomarker of exposure to fipronil.
Vasylieva N, Barnych B, Wan D, El-Sheikh EA, Nguyen HM, Wulff H, McMahen R, Strynar M, Gee SJ, Hammock BD.
Environ Int. 2017 Jun;103:91-98. doi: 10.1016/j.envint.2017.03.012. Epub 2017 Mar 23.
PMID: 28343720 [PubMed - in process]

Soluble epoxide hydrolase as a therapeutic target for pain, inflammatory and neurodegenerative diseases.
Wagner KM, McReynolds CB, Schmidt WK, Hammock BD.
Pharmacol Ther. 2017 Jun 19. pii: S0163-7258(17)30154-7. doi: 10.1016/j.pharmthera.2017.06.006. [Epub ahead of print] Review.
PMID: 28642117 [PubMed - as supplied by publisher]

Sensitive Immunoassay for Detection and Quantification of the Neurotoxin, Tetramethylenedisulfotetramine.
Vasylieva N, Barnych B, Rand A, Inceoglu B, Gee SJ, Hammock BD.
Analytical chemistry. 2017 May 16;89(10):5612-5619.
PubMed PMID: 28398746; PubMed Central PMCID: PMC5920647.

Soluble epoxide hydrolase inhibition alleviates neuropathy in Akita (Ins2 Akita) mice.
Wagner K, Gilda J, Yang J, Wan D, Morisseau C, Gomes AV, Hammock BD.
Behav Brain Res. 2017 May 30;326:69-76. doi: 10.1016/j.bbr.2017.02.048. Epub 2017 Mar 1.
PMID: 28259677 [PubMed - in process]

Synthesis of cyclooxygenase metabolites of 8,9-epoxyeicosatrienoic acid (EET): 11- and 15-hydroxy 8,9-EETs.
Barnych B, Rand AA, Cajka T, Lee KSS, Hammock BD.
Org Biomol Chem. 2017 May 23;15(20):4308-4313. doi: 10.1039/c7ob00789b.
PMID: 28470279 [PubMed - in process]

Structural Insights into the Atomistic Mechanisms of Action of Small Molecule Inhibitors Targeting the KCa3.1 Channel Pore.
Nguyen HM, Singh V, Pressly B, Jenkins DP, Wulff H, Yarov-Yarovoy V.
Mol Pharmacol. 2017 Apr;91(4):392-402. doi: 10.1124/mol.116.108068. Epub 2017 Jan 26.
PMID: 28126850 [PubMed - indexed for MEDLINE]

Nanostructure Introduces Artifacts in Quantitative Immunofluorescence by Influencing Fluorophore Intensity.
Chapman CA, Zhu X, Chen H, Yanik AA, Lein PJ, Seker E.
Sci Rep. 2017 Mar 27;7(1):427. doi: 10.1038/s41598-017-00447-7.
PMID: 28348397 [PubMed - in process]

Epoxy fatty acids mediate analgesia in murine diabetic neuropathy.
Wagner K, Lee KS, Yang J, Hammock BD.
Eur J Pain. 2017 Mar;21(3):456-465. doi: 10.1002/ejp.939. Epub 2016 Sep 15.
PMID: 27634339 [PubMed - in process]

Inhibition of soluble epoxide hydrolase augments astrocyte release of vascular endothelial growth factor and neuronal recovery after
oxygen-glucose deprivation.
Zhang Y, Hong G, Lee KS, Hammock BD, Gebremedhin D, Harder DR, Koehler RC, Sapirstein A.
J Neurochem. 2017 Mar;140(5):814-825. doi: 10.1111/jnc.13933. Epub 2017 Jan 23.
PMID: 28002622 [PubMed - indexed for MEDLINE]

Chemical synthesis and biological evaluation of ω-hydroxy polyunsaturated fatty acids.
Hwang SH, Wagner K, Xu J, Yang J, Li X, Cao Z, Morisseau C, Lee KS, Hammock BD.
Bioorg Med Chem Lett. 2017 Feb 1;27(3):620-625. doi: 10.1016/j.bmcl.2016.12.002. Epub 2016 Dec 2.
PMID: 28025003 [PubMed - indexed for MEDLINE]

Influence of tetramethylenedisulfotetramine on synchronous calcium oscillations at distinct developmental stages of hippocampal
neuronal cultures.
Cao Z, Xu J, Hulsizer S, Cui Y, Dong Y, Pessah IN.
Neurotoxicology. 2017 Jan;58:11-22. doi: 10.1016/j.neuro.2016.10.015. Epub 2016 Oct 29.
PMID: 27984050 [PubMed - in process]

Probing the orientation of inhibitor and epoxy-eicosatrienoic acid binding in the active site of soluble epoxide hydrolase.
Lee KS, Henriksen NM, Ng CJ, Yang J, Jia W, Morisseau C, Andaya A, Gilson MK, Hammock BD.
Arch Biochem Biophys. 2017 Jan 1;613:1-11. doi: 10.1016/ Epub 2016 Oct 29.
PMID: 27983948 [PubMed - indexed for MEDLINE]

Nanoporous Gold Biointerfaces: Modifying Nanostructure to Control Neural Cell Coverage and Enhance Electrophysiological Recording Performance.
Chapman CAR, Wang L, Chen H, Garrison J, Lein PJ, Seker E.
Adv Funct Mater. 2017 Jan 19;27(3). pii: 1604631. doi: 10.1002/adfm.201604631. Epub 2016 Dec 12.
PMID: 28626362 [PubMed]

Persistent neuroinflammation and cognitive impairment in a rat model of acute diisopropylfluorophosphate intoxication.
Flannery BM, Bruun DA, Rowland DJ, Banks CN, Austin AT, Kukis DL, Li Y, Ford BD, Tancredi DJ, Silverman JL, Cherry SR, Lein PJ.
J Neuroinflammation. 2016 Oct 12;13(1):267.
PMID: 27733171 [PubMed - in process]

VHH antibodies: emerging reagents for the analysis of environmental chemicals.
Bever CS, Dong JX, Vasylieva N, Barnych B, Cui Y, Xu ZL, Hammock BD, Gee SJ.
Anal Bioanal Chem. 2016 Sep;408(22):5985-6002. doi: 10.1007/s00216-016-9585-x. Epub 2016 May 21. Review.
PMID: 27209591 [PubMed - in process]

Mechanisms of Reduced Astrocyte Surface Coverage in Cortical Neuron-Glia Co-cultures on Nanoporous Gold Surfaces.
Chapman CA, Chen H, Stamou M, Lein PJ, Seker E.
Cell Mol Bioeng. 2016 Sep;9(3):433-442. Epub 2016 May 31.
PMID: 27795742 [PubMed]

Models to identify treatments for the acute and persistent effects of seizure-inducing chemical threat agents.
Pessah IN, Rogawski MA, Tancredi DJ, Wulff H, Zolkowska D, Bruun DA, Hammock BD, Lein PJ.
Ann N Y Acad Sci. 2016 Aug;1378(1):124-136. doi: 10.1111/nyas.13137. Epub 2016 Jul 28. Review.
PMID: 27467073 [PubMed - indexed for MEDLINE]

Inhibition of soluble epoxide hydrolase as a novel approach to high dose diazepam induced hypotension.
Ulu A, Inceoglu B, Yang J, Singh V, Vito S, Wulff H, Hammock BD.
J Clin Toxicol. 2016 Jun;6(3). pii: 1000300. doi: 10.4172/2161-0495.1000300. Epub 2016 May 30.
PMID: 28255523 [PubMed]

Novel Omega-3 Fatty Acid Epoxygenase Metabolite Reduces Kidney Fibrosis.
Sharma A, Hye Khan MA, Levick SP, Lee KS, Hammock BD, Imig JD.
Int J Mol Sci. 2016 May 18;17(5). pii: E751. doi: 10.3390/ijms17050751.
PMID: 27213332 [PubMed - indexed for MEDLINE]

Dietary linoleic acid-induced alterations in pro- and anti-nociceptive lipid autacoids: Implications for idiopathic pain syndromes?
Ramsden CE, Ringel A, Majchrzak-Hong SF, Yang J, Blanchard H, Zamora D, Loewke JD, Rapoport SI, Hibbeln JR, Davis JM, Hammock BD, Taha AY.
Mol Pain. 2016 Mar 10;12. pii: 1744806916636386. doi: 10.1177/1744806916636386. Print 2016.
PMID: 27030719 [PubMed - indexed for MEDLINE]

Pro-atherogenic role of smooth muscle Nox4-based NADPH oxidase.
Tong X, Khandelwal AR, Wu X, Xu Z, Yu W, Chen C, Zhao W, Yang J, Qin Z, Weisbrod RM, Seta F, Ago T, Lee KS, Hammock BD, Sadoshima J,
Cohen RA, Zeng C.
J Mol Cell Cardiol. 2016 Mar;92:30-40. doi: 10.1016/j.yjmcc.2016.01.020. Epub 2016 Jan 23.
PMID: 26812119 [PubMed - indexed for MEDLINE]

Recent developments in ion channel pharmacology.
Wulff H, Christophersen P.
Channels (Austin). 2015;9(6):335. doi: 10.1080/19336950.2015.1077650. Epub 2015 Nov 17. No abstract available.\
PMID: 26646476 [PubMed - indexed for MEDLINE]

Contrasting actions of a convulsant barbiturate and its anticonvulsant enantiomer on the α1 β3 γ2L GABAA receptor account for their in vivo effects.
Desai R, Savechenkov PY, Zolkowska D, Ge RL, Rogawski MA, Bruzik KS, Forman SA, Raines DE, Miller KW.
J Physiol. 2015 Nov 15;593(22):4943-61. doi: 10.1113/JP270971.
PMID: 26378885 [PubMed - indexed for MEDLINE]

Combined treatment with diazepam and allopregnanolone reverses tetramethylenedisulfotetramine (TETS)-induced calcium dysregulation
in cultured neurons and protects TETS-intoxicated mice against lethal seizures.
Bruun DA, Cao Z, Inceoglu B, Vito ST, Austin AT, Hulsizer S, Hammock BD, Tancredi DJ, Rogawski MA, Pessah IN, Lein PJ.
Neuropharmacology. 2015 Aug;95:332-42. doi: 10.1016/j.neuropharm.2015.03.035. Epub 2015 Apr 14.

Development of an Immunoassay for the Detection of the Phenylpyrazole Insecticide Fipronil.
Vasylieva N, Ahn KC, Barnych B, Gee SJ, Hammock BD.
Environ Sci Technol. 2015 Aug 18;49(16):10038-47. doi: 10.1021/acs.est.5b01005. Epub 2015 Aug 5.
PMID: 26196357 [PubMed - indexed for MEDLINE]
PMID: 25882826 [PubMed - indexed for MEDLINE]

Endoplasmic reticulum stress in the peripheral nervous system is a significant driver of neuropathic pain.
Inceoglu B, Bettaieb A, Trindade da Silva CA, Lee KS, Haj FG, Hammock BD.\
Proc Natl Acad Sci U S A. 2015 Jul 21;112(29):9082-7. doi: 10.1073/pnas.1510137112. Epub 2015 Jul 6.
PMID: 26150506 [PubMed - indexed for MEDLINE]

The Alzheimer's Disease Neuroimaging Initiative phase 2: Increasing the length, breadth, and depth of our understanding.
Beckett LA, Donohue MC, Wang C, Aisen P, Harvey DJ, Saito N; Alzheimer's Disease Neuroimaging Initiative.
Alzheimers Dement. 2015 Jul;11(7):823-31. doi: 10.1016/j.jalz.2015.05.004. Review.
PMID: 26194315 [PubMed - indexed for MEDLINE]

Peripheral FAAH and soluble epoxide hydrolase inhibitors are synergistically antinociceptive.
Sasso O, Wagner K, Morisseau C, Inceoglu B, Hammock BD, Piomelli D.
Pharmacol Res. 2015 Jul;97:7-15. doi: 10.1016/j.phrs.2015.04.001. Epub 2015 Apr 14.
PMID: 25882247 [PubMed - indexed for MEDLINE]

Pharmacological gating modulation of small- and intermediate-conductance Ca(2+)-activated K(+) channels (KCa2.x and KCa3.1).
Christophersen P, Wulff H.
Channels (Austin). 2015;9(6):336-43. doi: 10.1080/19336950.2015.1071748. Epub 2015 Jul 28. Review.
PMID: 26217968 [PubMed - indexed for MEDLINE]

High salt intake increases blood pressure in normal rats: putative role of 20-HETE and no evidence on changes in renal vascular reactivity.
Walkowska A, Kuczeriszka M, Sadowski J, Olszyñski KH, Dobrowolski L, Červenka L, Hammock BD, Kompanowska-Jezierska E.
Kidney Blood Press Res. 2015;40(3):323-34. doi: 10.1159/000368508. Epub 2015 May 31.
PMID: 26067851 [PubMed - indexed for MEDLINE]

Rapid throughput analysis demonstrates that chemicals with distinct seizurogenic mechanisms differentially alter Ca2+ dynamics in networks
formed by hippocampal neurons in culture.
Cao Z, Zou X, Cui Y, Hulsizer S, Lein PJ, Wulff H, Pessah IN.
Mol Pharmacol. 2015 Apr;87(4):595-605. doi: 10.1124/mol.114.096701. Epub 2015 Jan 12.
PMID: 25583085 [PubMed - indexed for MEDLINE]

Nanoporous gold as a neural interface coating: effects of topography, surface chemistry, and feature size.
Chapman CA, Chen H, Stamou M, Biener J, Biener MM, Lein PJ, Seker E.
ACS Appl Mater Interfaces. 2015 Apr 8;7(13):7093-100. doi: 10.1021/acsami.5b00410. Epub 2015 Mar 2.
PMID: 25706691 [PubMed - indexed for MEDLINE]

Neuregulin-1 inhibits neuroinflammatory responses in a rat model of organophosphate-nerve agent-induced delayed neuronal injury.
Li Y, Lein PJ, Ford GD, Liu C, Stovall KC, White TE, Bruun DA, Tewolde T, Gates AS, Distel TJ, Surles-Zeigler MC, Ford BD.
J Neuroinflammation. 2015 Apr 2;12:64. doi: 10.1186/s12974-015-0283-y.
PMID: 25880399 [PubMed - indexed for MEDLINE]

Current understanding of the mechanism of action of the antiepileptic drug lacosamide.
Rogawski MA, Tofighy A, White HS, Matagne A, Wolff C.
Epilepsy Res. 2015 Feb;110:189-205. doi: 10.1016/j.eplepsyres.2014.11.021. Epub 2014 Dec 3. Review.
PMID: 25616473 [PubMed - indexed for MEDLINE]

Potent natural soluble epoxide hydrolase inhibitors from Pentadiplandra brazzeana baillon: synthesis, quantification, and measurement of
biological activities in vitro and in vivo.
Kitamura S, Morisseau C, Inceoglu B, Kamita SG, De Nicola GR, Nyegue M, Hammock BD.
PLoS One. 2015 Feb 6;10(2):e0117438. doi: 10.1371/journal.pone.0117438. eCollection 2015.
PMID: 25659109 [PubMed - indexed for MEDLINE]

PPARδ signaling mediates the cytotoxicity of DHA in H9c2 cells.
Samokhvalov V, Zlobine I, Jamieson KL, Jurasz P, Chen C, Lee KS, Hammock BD, Seubert JM.
Toxicol Lett. 2015 Jan 5;232(1):10-20. doi: 10.1016/j.toxlet.2014.09.029. Epub 2014 Oct 6.
PMID: 25300478 [PubMed - indexed for MEDLINE]

The riluzole derivative 2-amino-6-trifluoromethylthio-benzothiazole (SKA-19), a mixed KCa2 activator and NaV blocker, is a potent novel
Coleman N, Nguyen HM, Cao Z, Brown BM, Jenkins DP, Zolkowska D, Chen YJ, Tanaka BS, Goldin AL, Rogawski MA, Pessah IN, Wulff H.
Neurotherapeutics. 2015 Jan;12(1):234-49. doi: 10.1007/s13311-014-0305-y.
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Behavioral assessment of NIH Swiss mice acutely intoxicated with tetramethylenedisulfotetramine.
Flannery BM, Silverman JL, Bruun DA, Puhger KR, McCoy MR, Hammock BD, Crawley JN, Lein PJ.
Neurotoxicol Teratol. 2015 Jan-Feb;47:36-45. doi: 10.1016/ Epub 2014 Nov 8.
PMID: 25446016 [PubMed - indexed for MEDLINE]

Factors influencing adverse skin responses in rats receiving repeated subcutaneous injections and potential impact on neurobehavior.
Levoe SN, Flannery BM, Brignolo L, Imai DM, Koehne A, Austin AT, Bruun DA, Tancredi DJ, Lein PJ.
Curr Neurobiol. 2014 Dec 1;5(1-2):1-10.
PMID: 25705100 [PubMed]

Pediatric super-refractory status epilepticus treated with allopregnanolone.
Broomall E, Natale JE, Grimason M, Goldstein J, Smith CM, Chang C, Kanes S, Rogawski MA, Wainwright MS.
Ann Neurol. 2014 Dec;76(6):911-5. doi: 10.1002/ana.24295. Epub 2014 Nov 11.
PMID: 25363147 [PubMed - indexed for MEDLINE]

Post-exposure administration of diazepam combined with soluble epoxide hydrolase inhibition stops seizures and modulates neuroinflammation
in a murine model of acute TETS intoxication.
Vito ST, Austin AT, Banks CN, Inceoglu B, Bruun DA, Zolkowska D, Tancredi DJ, Rogawski MA, Hammock BD, Lein PJ.
Toxicol Appl Pharmacol. 2014 Dec 1;281(2):185-94. doi: 10.1016/j.taap.2014.10.001. Epub 2014 Oct 14.
PMID: 25448683 [PubMed - indexed for MEDLINE]

The role of long chain fatty acids and their epoxide metabolites in nociceptive signaling.
Wagner K, Vito S, Inceoglu B, Hammock BD.
Prostaglandins Other Lipid Mediat. 2014 Oct;113-115:2-12. doi: 10.1016/j.prostaglandins.2014.09.001. Epub 2014 Sep 18. Review.
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Anticonvulsant potencies of the enantiomers of the neurosteroids androsterone and etiocholanolone exceed those of the natural forms.
Zolkowska D, Dhir A, Krishnan K, Covey DF, Rogawski MA.
Psychopharmacology (Berl). 2014 Sep;231(17):3325-32. doi: 10.1007/s00213-014-3546-x. Epub 2014 Apr 5.
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New positive Ca2+-activated K+ channel gating modulators with selectivity for KCa3.1.
Coleman N, Brown BM, Oliván-Viguera A, Singh V, Olmstead MM, Valero MS, Köhler R, Wulff H.
Mol Pharmacol. 2014 Sep;86(3):342-57. doi: 10.1124/mol.114.093286. Epub 2014 Jun 23.
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Perampanel inhibition of AMPA receptor currents in cultured hippocampal neurons.
Chen CY, Matt L, Hell JW, Rogawski MA.
PLoS One. 2014 Sep 17;9(9):e108021. doi: 10.1371/journal.pone.0108021. eCollection 2014.
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Optimized inhibitors of soluble epoxide hydrolase improve in vitro target residence time and in vivo efficacy.
Lee KS, Liu JY, Wagner KM, Pakhomova S, Dong H, Morisseau C, Fu SH, Yang J, Wang P, Ulu A, Mate CA, Nguyen LV, Hwang SH, Edin ML,
Mara AA, Wulff H, Newcomer ME, Zeldin DC, Hammock BD.
J Med Chem. 2014 Aug 28;57(16):7016-30. doi: 10.1021/jm500694p. Epub 2014 Aug 11.
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GABAA receptor target of tetramethylenedisulfotetramine.
Zhao C, Hwang SH, Buchholz BA, Carpenter TS, Lightstone FC, Yang J, Hammock BD, Casida JE.
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Nanomolar bifenthrin alters synchronous Ca2+ oscillations and cortical neuron development independent of sodium channel activity.
Cao Z, Cui Y, Nguyen HM, Jenkins DP, Wulff H, Pessah IN.
Mol Pharmacol. 2014 Apr;85(4):630-9. doi: 10.1124/mol.113.090076. Epub 2014 Jan 30.
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The potential of antiseizure drugs and agents that act on novel molecular targets as antiepileptogenic treatments.
Kaminski RM, Rogawski MA, Klitgaard H.
Neurotherapeutics. 2014 Apr;11(2):385-400. doi: 10.1007/s13311-014-0266-1. Review.
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Role of GluK1 kainate receptors in seizures, epileptic discharges, and epileptogenesis.
Fritsch B, Reis J, Gasior M, Kaminski RM, Rogawski MA.
J Neurosci. 2014 Apr 23;34(17):5765-75. doi: 10.1523/JNEUROSCI.5307-13.2014.
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Inhibition of soluble epoxide hydrolase is renoprotective in 5/6 nephrectomized Ren-2 transgenic hypertensive rats.
Kujal P, Čertíková Chábová V, Škaroupková P, Husková Z, Vernerová Z, Kramer HJ, Walkowska A, Kompanowska-Jezierska E, Sadowski J,
Kitada K, Nishiyama A, Hwang SH, Hammock BD, Imig JD, Červenka L.
Clin Exp Pharmacol Physiol. 2014 Mar;41(3):227-37. doi: 10.1111/1440-1681.12204.
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Soluble epoxide hydrolase inhibitor trans-4-[4-(3-adamantan-1-yl-ureido)-cyclohexyloxy]-benzoic acid is neuroprotective in rat model of ischemic
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Synthesis and biological evaluation of sorafenib- and regorafenib-like sEH inhibitors.
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