CounterACT Center Publications
A longitudinal MRI and TSPO PET-based investigation of brain region-specific neuroprotection by diazepam versus midazolam following organophosphate-induced seizures.
Hobson BA, Rowland DR, Dou Y, Saito N, Harmany ZT, Bruun DA, Harvey DJ, Chaudhari A, Garbow JR, Lein PJ.
Neuropharmacology. 2024 Jun 15:251:109918. PMCID: PMC11250911
Quantitative T2 mapping-based longitudinal assessment of brain injury and therapeutic rescue in the rat following acute organophosphate intoxication.
Almeida AJD, Hobson BA, Saito N, Bruun DA, Porter VA, Harvey DJ, Garbow JR, Chaudhari AJ, Lein PJ.
Neuropharmacology. 2024 May 15;249:109895. PMCID: PMC11227117
Fully automated whole brain segmentation from rat MRI scans with a convolutional neural network.
Porter VA, Hobson BA, Foster B, Lein PJ, Chaudhari AJ.J
Neurosci Methods. 2024 May:405:110078. PMCID: PMC11000587 (available on 2025-02-01)
Cardiovascular responses of adult male Sprague-Dawley rats following acute organophosphate intoxication and post-exposure treatment with midazolam with or without allopregnanolone.
Pan S, Bruun DA, Lein PJ, Chen CY.
Arch Toxicol. 2024 Apr;98(4):1177-1189. PMCID: PMC10944447
Acute intoxication with diisopropylfluorophosphate promotes cellular senescence in the adult male rat brain.
Tsai YH, González EA, Grodzki AC, Bruun DA, Saito NH, Harvey DJ, Lein PJ.
Front Toxicol. 2024 Apr; 6: 1360359. doi: 10.3389/ftox.2024.1360359. PMCID: PMC11091247
The α4 nicotinic acetylcholine receptor Is necessary for the initiation of organophosphate-induced neuronal hyperexcitability.
Andrew PM, Feng W, Calsbeek JJ, Antrobus SP, Cherednychenko GA, MacMahon JA, Bernardino PN, Liu X, Harvey DJ, Lein PJ, Pessah IN.
Toxics. 2024 Mar 31;12(4):263 PMCID: PMC11054284
Inhibition of soluble epoxide hydrolase reduces inflammation and myocardial injury in arrhythmogenic cardiomyopathy.
Panigrahy D, Kelly AG, Wang W, Yang J, Hwang SH, Gillespie M, Howard I, Bueno-Beti C, Asimaki A, Penna V, Lavine K, Edin ML, Zeldin DC, Hammock BD, Saffitz JE.
bioRxiv [Preprint]. 2024 Feb 19:2024.02.17.580812. PMCID: PMC10925075
Evidence implicating blood-brain barrier impairment in the pathogenesis of acquired epilepsy following acute organophosphate intoxication.
Bernardino PN, Luo AS, Andrew PM, Unkel CM, Gonzalez MI, Gelli A, Lein PJ.
J Pharmacol Exp Ther. 2024 Jan 17;388(2):301-312. PMCID: PMC10801776
Soluble epoxide hydrolase-targeting PROTAC activates AMPK and inhibits endoplasmic reticulum stress.
Peyman M, Barroso E, Turcu AL, Estrany Jr, F; Smith D, Jurado-Aguilar J, Rada P, Morisseau C, Hammock BD, Valverde ÁM, Palomer X, Galdeano C, Vázquez S, Vázquez-Carrera M.
Biomed Pharmacother 2023 Dec:168:115667. PMCID: PMC10786198 (available on 2024-12-01)
Determinants of meal-induced changes in circulating FFA epoxides, diols, and diol-to-epoxide ratios as indices of soluble epoxide hydrolase activity.
Oh YT, Yang J, Stefanovski D, Hammock B, Youn JH.
Int J Mol Sci. 2023 Dec 11;24(24):17351. PMCID: PMC10743433.
Time- and region-dependent blood-brain barrier impairment in a rat model of organophosphate-induced status epilepticus.
Bernardino PN, Hobson BA, Huddleston SL, Andrew PM, MacMahon JA, Saito NH, Porter VA, Bruun DA, Harvey DJ, Garbow JR, Gelli A, Chaudhari AJ, Lein PJ.
Neurobiol Dis. 2023 Oct 15;187:106316. PMCID: PMC11000668.
The rehabilitation potential of neurostimulation for mild traumatic brain injury in animal and human studies.
McNerney MW, Gurkoff GG, Beard C, Berryhill ME.
Brain Sci. 2023 Sep 30;13(10):1402. PMCID: PMC10605899
Quantification of soluble epoxide hydrolase inhibitors in experimental and clinical samples using the nanobody-based ELISA.
Yang H, Qi M, He Q, Hwang SH, Yang J, McCoy M, Morisseau C, Zhao S, Hammock BD.
J Pharm Anal. 2023 Sep; 13(9):1013–1023. PMCID: PMC10568103
Tolerability and pharmacokinetics of intravenous allopregnanolone with and without midazolam pretreatment in two healthy dogs.
Bruun DA, Ma B, Chen YJ, Wu CY, Aleman M, Zolkowska D, Smiley-Jewell SM, Rogawski MA, Lein PJ.
Epilepsia Open. 2023 Jun;8(2):666-672. PMCID: PMC10235566
Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) causes seizure activity in larval zebrafish via antagonism of γ-aminobutyric acid type A receptor α1β2γ2.
Mundy PC, Werner A, Singh L, Singh V, Mendieta R, Patullo CE, Wulff H, Lein PJ.
Arch Toxicol. 2023 May;97(5):1355-1365. PMCID: PMC10110628
Cmpd10357 to treat B-cell acute lymphoblastic leukemia
Lee AQ, Konishi H, Helmke E, Ijiri M, Lerot JMA, Hicks E, Chien JR, Gorin FA, Satake N
Experimental Hematology. 2023 Mar-Apr;119-120:8-13.e1. PMCID: PMC10033359
Novel image analysis tool for rapid screening of cell morphology in preclinical animal models of disease.
Guignet M, Schmuck M, Harvey DJ, Nguyen D, Bruun D, Echeverri A, Gurkoff G, Lein PJ. Heliyon. 2023 Feb 8;9(2):e13449. PMCID: PMC9975095.
The seizure-inducing plastic explosive RDX inhibits the α1β2γ2 GABA A receptor
Pressly B, Lee RD, Singh V, Pessah IN, Wulff H
Ann Clin Transl Neurol. 2022; 9(5):600-609. PMC9082378
Diisopropylfluorophosphate (DFP) volatizes and cross-contaminates wells in a common 96-well plate format used in zebrafish larvae toxicology studies.
Mundy PC, Mendieta R, Lein PJ.
J Pharmacol Toxicol Methods. 2022 May-Jun 2022;115:107173. PMCID: PMC9356770
A fast and selective approach for profiling vicinal diols using liquid chromatography-post column derivatization-double precursor ion scanning mass spectrometry
Wan D, Morisseau C, Hammock BD, Yang J
Molecules. 2022;27:283. PMCID: PMC8747065
Improved ELISA for linoleate-derived diols in human plasma utilizing a polyHRP-based secondary tracer
Singh N, Li D, McReynolds CB, Morisseau C, Hammock BD
Analytical Methods. 2022;14:1810-19. PMCID: PMC9116231
Intramuscular dose of midazolam in rats producing exposure equivalent to recommended dose of Seizalam® (midazolam injection) in humans
Dhir A, Wu C-Y, Rogawski MA
Program No. P077.05 2021 Neuroscience Meeting Planner, p. 413. Chicago, IL: Society for Neuroscience, 2021. Online.
Estimation of the intramuscular dose of midazolam in mice to achieve the therapeutic plasma concentration effective for the treatment of status epilepticus in humans
Zolkowska D, Wu C-Y, Stone C, Rogawski MA
American Epilepsy Society Annual Meeting, Abstract 1.135, Translational Research, 2021 Dec 4.
Sex-specific acute and chronic neurotoxicity of acute diisopropylfluorophosphate (DFP)-intoxication in juvenile Sprague-Dawley rats
González EA, Calsbeek JJ, Tsai Y-H, Tang M-Y, Andrew P, Vu J, Berg EL, Saito NH, Harvey DJ, Supasai S, Gurkoff GG, Silverman JL, Lein PJ
Current Research in Toxicology. 2021 Sep 14. 2:341-356. PMCID: PMC8484742
Persistent neuropathology and behavioral deficits in a mouse model of status epilepticus induced by acute intoxication with diisopropylfluorophosphate
Calsbeek JJ, González EA, Bruun DA, Guignet MA, Copping N, Dawson ME, Yu AJ, MacMahon JA, Saito NH, Harvey DJ, Silverman JL, Lein PJ.
Neurotoxicology. 2021 Sep 9:S0161-813X(21)00113-3. PMCID: PMC8595753
The efficacy of γ-aminobutyric acid type A receptor (GABA AR) subtype-selective positive allosteric modulators in blocking tetramethylenedisulfotetramine (TETS)-induced seizure-like behavior in larval zebrafish with minimal sedation
Mundy PC, Pressly B, Carty DR, Yaghoobi B, Wulff H, Lein PJ.
Toxicol Appl Pharmacol. 2021 Sep 1;426:115643. PMCID: PMC8514104
Strain differences in the extent of brain injury in mice after tetramethylenedisulfotetramine-induced status epilepticus
Calsbeek JJ, González EA, Boosalis CA, Zolkowska D, Bruun DA, Rowland DJ, Saito NH, Harvey DJ, Chaudhari AJ, Rogawski MA, Garbow JR, Lein PJ
NeuroToxicology. 2021 Aug 31; 87:43-50. PMCID: PMC8595842
Neuroinflammation as a therapeutic target for mitigating the long-term consequences of acute organophosphate intoxication
Andrew PM and Lein PJ
Front Pharmacol. 2021 May 12;12:674325. PMCID: PMC8153682
Mechanisms of organophosphate neurotoxicity
Tsai Y-H and Lein PJ
Current Opinion in Tox, 2021 April; 26:49-60. PMCID: PMC8302047
Perampanel, a potent AMPA receptor antagonist, protects against tetramethylenedisulfotetramine-induced seizures and lethality in mice: comparison with diazepam
Zolkowska D, Dhir A, Rogawski
Arch Toxicol. 2021 Jul;95(7):2459-2468. PMCID: PMC8241714
Colocalization of fluorescent signals using deep learning with Manders overlapping coefficient
Dou Y, Tsai Y-H, Liu CC, Hobson BA, Lein PJ
Proc SPIE Int Soc Opt Eng. 2021 Feb;11596-115963C. PMCID: PMC8301216
Identification of the functional binding site for the convulsant tetramethylenedisulfotetramine in the pore of the α 2 β 3 γ 2 GABAA receptor
Pressly B, Lee RD, Barnych B, Hammock BD, Wulff H
Mol Pharmacol. 2021 Jan;99(1):78-91. PMCID: PMC7746976
Structure-activity relationship of neuroactive steroids, midazolam, and perampanel towards mitigating tetramine-triggered activity in murine hippocampal neuronal networks
Antrobus S, Pressly B, Nik AM, Wulff H, Pessah IN
Toxicol Sci. 2021 Apr 12;180(2):325-341. PMCID: PMC8599726
Intranasal allopregnanolone confers rapid seizure protection: Evidence for direct nose-to-brain delivery
Zolkowska D, Wu CY, Rogawski MA
Neurotherapeutics. 2021 Jan;18(1):544-555. PMCID: PMC8116426
Letter to Editor: Requiring post-hoc power of 80% amounts to an unstated lowering of the type-1 error rate
Tancredi DJ, Harvey DJ, Smiley-Jewell S, Nguyen DV
Neurotoxicology. 2021 Jan;82:99. PMID: 33232746
Plasma linoleate diols are potential biomarkers for severe COVID-19 infections
McReynolds CB, Cortes-Puch I, Ravindran R, Khan IH, Hammock BG, Shih P-aB, Hammock BD, Yang J
Frontiers in Physiology. 2021;12:663869. PMCID: PMC8047414
TPPU treatment of burned mice dampens inflammation and generation of bioactive DHET which impairs neutrophil function
Bergmann CB, Hammock BD, Wan D, Gogolla F, Goetzman H, Caldwell CC, Supp DM
Scientific Reports. 2021;11:16555. PMCID: PMC8368302
Species differences in metabolism of soluble epoxide hydrolase inhibitor, EC1728, highlight the importance of clinically relevant screening mechanisms in drug development
McReynolds CB, Yang J, Guedes A, Morisseau C, Garcia R, Knych H, Tearny C, Hwang SH, Wagner K, Hammock BD
Molecules. 2021;26:5034. PMCID: PMC8399023
Movement to the clinic of soluble epoxide hydrolase inhibitor EC5026 as an analgesic for neuropathic pain and for use as a nonaddictive opioid alternative
Hammock BD, McReynolds CB, Wagner K, Buckpitt A, Cortes-Puch I, Croston G, Lee KS, Yang J, Schmidt WK, Hwang SH
J Med Chem. 2021;64:1856-72. PMCID: PMC7917437
New capsaicin analogs as molecular rulers to define the permissive conformation of the mouse TRPV1 ligand-binding pocket
Vu S, Singh V, Wulff H, Yarov-Yarovoy V, Zheng J
eLife 2020 Nov 9;e62039. PMCID: PMC7671684
Acute administration of diazepam or midazolam minimally alters long-term neuropathological effects in the rat brain following acute intoxication with diisopropylfluorophosphate
Supasai S, González EA, Rowland DJ, Hobson B, Bruun DA, Guignet MA, Soares S, Singh V, Wulff H, Saito N, Harvey DJ, Lein PJ
Eur J Pharmacol. 2020 Nov 5;886:173538. PMCID: PMC7572820
Allopregnanolone and perampanel as adjuncts to midazolam for treating diisopropylfluorophosphate-induced status epilepticus in rats
Dhir A, Bruun DA, Guignet M, Tsai Y-H, González E, Calsbeek J, Vu J, Saito N, Tancredi DJ, Harvey DJ, Lein PJ, Rogawski MA
Ann NY Acad Sci 2020 Sep 11, 1-23. PMCID: PMC7756871
A national toxicology program systematic review of the evidence for long-term effects after acute exposure to sarin nerve agent
Jett DA, Sibrizzi CA, Blain RB, Hartman PA, Lein PJ, Taylor KW, Rooney AA
Critical Reviews in Toxicology 2020 Aug 5;1-17. PMCID: PMC8011809
Soluble epoxide hydrolase regulation of lipid mediators limits pain
Wagner KM, Gomes A, McReynolds CB, Hammock BD.
Neurotherapeutics. 2020 Jul;17(3):900-916. PMCID: PMC7609775
The chemical convulsant diisopropylfluorophosphate (DFP) causes persistent neuropathology in adult male rats independent of seizure activity
González EA, Rindy AC, Guignet MA, Calsbeek JJ, Bruun DA, Dhir A, Andrew P, Saito N, Rowland DJ, Harvey DJ, Rogawski MA, Lein PJ .
Archives In Toxicolology 2020 June;94:2149-2162. PMCID: PMC7305973
Comparison of the toxicokinetics of the convulsants picrotoxinin and tetramethylenedisulfotetramine (TETS) in mice
Pressly B. Vasylieva N. Barnych B, Singh V. Bruun DA, Hwang SH. Chen YJ, Johnnides S, Lein PJ. Yang J, Hammock BD, Wulff H
Archives in Toxicology 2020 June:9494(6):1995-2007. PMCID: PMC7303059
Soluble epoxide hydrolase inhibitor mediated analgesia lacks tolerance in rat models
Wagner KM, Atone J, Hammock BD
Brain research. 2020 February 1;1728:146573. PMCID: PMC6996511
Pharmacology of small- and intermediate-conductance calcium-activated potassium channels
Brown BM, Shim H, Christophersen P, Wulff H
Annu Rev Pharmacol Toxicol. 2020;60:219-240. PMID 31337271
National Institutes of Neurological Disorders and Stroke (NINDS)/American Epilepsy Society (AES) epilepsy research benchmark stewards. Epilepsy benchmarks area III: Improved treatment options for controlling seizures and epilepsy-related conditions without side effects
Traynelis SF, Dlugos D, Henshall D, Mefford HC, Rogawski MA, Staley KJ, Dacks PA, Whittemore V, Poduri A
Epilepsy Curr. 2020 Jan-Feb;20(1_suppl):23S-30S. PMCID: PMC7031805.
Susceptibility of larval zebrafish to the seizurogenic activity of GABA type A receptor antagonists
Bandara SB, Carty DR, Singh V, Harvey DJ, Vasylieva N, Pressly B, Wulff H, Lein PJ
Neurotoxicology. 2020 Jan;76:220-234. PMCID: PMC6957304
Persistent behavioral deficits, neuroinflammation and oxidative stress in a rat model of acute organophosphate intoxication
Guignet M, Dhakal K, Flannery BM, Hobson BA, Zolkowska D, Dhir A, Bruun DA, Li S, Harvey DJ, Silverman JL, Rogawski MA, Lein PJ
Neurobiol Dis. 2020 Jan;133:104431. PMCID: PMC6754818
A permethrin metabolite is associated with adaptive immune responses in Gulf War Illness
Joshi U, Pearson A, Evans JE, Langlois H. Saltiel N, Ojo J, Klimas N, Sullivan K, Keegan AP, Oberlin S, Darcey T, Cseresznye A, Raya B. Paris D, Hammock B, Vasylieva N, Hongsibsong S, Stern LJ, Crawford F, Mullan M, Abdullah L
Brain, Behavior, and Immunity 2019:81:545-559. PMID 31325531; PMCID: PMC7155744
Lipidomes of brain from rats acutely intoxicated with diisopropylfluorophosphate identifies potential therapeutic targets
Yang J, Bruun DA, Wang C, Wan D, McReynolds CB, Phu K, Inceoglu B, Lein PJ, Hammock BD
Toxicol Appl Pharmacol. 2019 Nov 1;382:114749. PMID: 31521729; PMCID: PMC6957308
Acute peripheral immune activation alters cytokine expression and glial activation in the early postnatal rat brain
Bruce M, Streifel KM, Boosalis CA, Heuer L, González EA, Li S, Harvey DJ, Lein PJ, Van de Water J
J Neuroinflammation. 2019 Oct 31;16(1):200. PMID: 31672161; PubMed Central PMCID: PMC6822372.
Pretreatment with pyridostigmine bromide has no effect on seizure behavior or 24 hour survival in the rat model of acute diisopropylfluorophosphate intoxication
Bruun DA, Guignet M, Harvey DJ, Lein PJ
Neurotoxicology. 2019 Jul;73:81-84 PMID: 30853371; PMCID: PMC66344995
The use of percent change in RR interval for data exclusion in analyzing 24 hour time domain heart rate variability in rats
Karey E, Pan S, Morris A, Bruun DA, Lein PJ, Chen CY
Front. Physiol., 2019 Jun;10:693. PMID: 31244671; PMCID: PMC6562196
TSPO PET using [18F]PBR111 reveals persistent neuroinflammation following acute diisopropylfluorophosphate intoxication in the rat
Hobson BA, Rowland DJ, Siso S, Guignet MA, Harmany ZT, Bandara S, Saito N, Harvey DJ, Bruun DA, Garbow JR, Chaudhari AF, Lein PJ
Toxicol Sci. 2019: 170(2):330-344. PMC6657665; PMCID: PMC6657665
Antibodies and venom peptides: new modalities for ion channels
Wulff H, Christophersen P, Colussi P, Chandy KG, Yarov-Yarovoy V
Nat Rev Drug Discov. 2019 May;18(5):339-357. PMID: 30728472; PMCID: PMC6499689
Organophosphates
Guignet M, Lein PJ
In: Advances in Neurotoxicology: Role of Inflammation in Environmental Neurotoxicity, volume 3 (Edited by M Aschner, LG Costa), Academic Press, Cambridge, MA, pp. 35-79. 2019
1-Trifluoromethoxyphenyl-3-(1-propionylpiperidin-4-yl) urea, a selective and potent dual inhibitor of soluble epoxide hydrolase and p38 kinase intervenes in Alzheimer's signaling in human nerve cells
Liang Z, Zhang B, Xu M, Morisseau C, Hwang SH, Hammock BD, Li QX
ACS Chem Neurosci. 2019;10:4018-4030. PMC 7028313; PMCID: PMC7028313
The pharmacokinetics of ketamine following intramuscular injection to F344 rats
Moeller B, Espelien B, Weber W, Kuehl P, Doyle-Eisele M, Garner CE, McDonald JD, Garcia E, Raulli R, Laney J
Drug Test Anal.2019 Jan;11(1):68-76. doi: 10.1002/dta.2468. PMID: 30027605; PMCID: .PMC6538562
Soluble epoxide hydrolase inhibitor, APAU, protects dopaminergic neurons against rotenone induced neurotoxicity: Implications for Parkinson's disease
Lakkappa N, Krishnamurthy PT, M D P, Hammock BD, Hwang SH
Neurotoxicology. 2019 January;70:135-145. PMID: 30472438; PMCID: PMC6873230
The trials and tribulations of structure assisted design of KCa channel activators
Shim H, Brown BM, Singh L, Singh V, Fettinger JC, Yarov-Yarovoy V, Wulff H
Front Pharmacol. 2019;10:972. PMC6764326; PMCID: PMC6764326
In vitro and in vivo metabolism of a potent inhibitor of soluble epoxide hydrolase, 1-(1-Propionylpiperidin-4-yl)-3-(4-(trifluoromethoxy)phenyl)urea
Wan D, Yang J, McReynolds CB, Barnych B, Wagner KM, Morisseau C, Hwang SH, Sun J, Blöcher R, Hammock BD
Front. Pharmacol. 2019;10:464. PMC6520522; PMCID: PMC6520522
Anti-inflammatory treatment with a soluble epoxide hydrolase inhibitor attenuates seizures and epilepsy-associated depression in the LiCl-pilocarpine post-status epilepticus rat model
Shen Y, Peng W. Chen Q. Hammock BD, Liu J, Li D, Yang J, Ding J, Wang X
Brain, Behavior, and Immunity 2019;81:535-544. PMC6873816; PMCID: PMC6873816
A magnetic resonance imaging study of early brain injury in a rat model of acute DFP intoxication
Hobson BA, Rowland DJ, Supasai S, Harvey DJ, Lein PJ, Garbow JR
Neurotoxicology. 2018 May;66:170-178. PMID: 29183789; PMCID: PMC5940565
Intramuscular allopregnanolone and ganaxolone in a mouse model of treatment-resistant status epilepticus
Zolkowska D, Wu CY, Rogawski MA.
Epilepsia. 2018 October;59 Suppl 2:220-227. PMID: 29453777; PMCID: PMC6910080
Bifenthrin causes transcriptomic alterations in mTOR and ryanodine receptor-dependent signaling and delayed hyperactivity in developing zebrafish (Danio rerio)
Frank DF, Miller GW, Harvey DJ, Brander SM, Geist J, Connon RE, Lein PJ
Aquat Toxicol. 2018 Jul;200:50-61. PMID: 29727771
A Microfluidic Platform to Study Astrocyte Adhesion on Nanoporous Gold Thin Films
Hampe AE, Li Z, Sethi S, Lein PJ, Seker E
Nanomaterials (Basel, Switzerland). 2018 June 21;8(7).
PMID: 29933551; PMCID: PMC6070884.
Determination of minimal steady-state plasma level of diazepam causing seizure threshold elevation in rats
Dhir A, Rogawski MA
Epilepsia.2018 May;59(5):935-944. doi: 10.1111/epi.14069. Epub 2018 Apr 6. PMID: 29682729; PMCID: PMC5934328
Soluble epoxide hydrolase inhibition decreases reperfusion injury after focal cerebral ischemia
Tu R, Armstrong J, Lee KSS, Hammock BD, Sapirstein A, Koehler RC
Scientific Reports. 2018 March 27;8(1):5279. PMID: 29588470; PMCID: PMC5869703
COX-2/sEH Dual Inhibitor PTUPB Potentiates the Antitumor Efficacy of Cisplatin
Wang F, Zhang H, Ma AH, Yu W, Zimmermann M, Yang J, Hwang SH, Zhu D, Lin TY, Malfatti M, Turteltaub KW, Henderson PT, Airhart S, Hammock BD, Yuan J, de Vere White RW, Pan CX
Molecular cancer therapeutics. 2018 February;17(2):474-483. PMID: 29284644; PMCID: PMC5824635.
GABAA receptor subtype selectivity of the proconvulsant rodenticide TETS
Pressly B, Nguyen HM, Wulff H
Arch Toxicol. 2018 Feb;92(2):833-844. doi: 10.1007/s00204-017-2089-4. Epub 2017 Oct 16. PMID: 29038840
Structural Determinants for the Selectivity of the Positive KCa3.1 Gating Modulator 5-Methylnaphtho[2,1-d]oxazol-2-amine (SKA-121)
Brown BM, Shim H, Zhang M, Yarov-Yarovoy V, Wulff H
Mol Pharmacol. 2017 Oct;92(4):469-480. PMID: 28760780
Rapid Throughput Analysis of GABAAReceptor Subtype Modulators and Blockers Using DiSBAC1(3) Membrane Potential Red Dye
Nik AM, Pressly B, Singh V, Antrobus S, Hulsizer S, Rogawski MA, Wulff H, Pessah IN
Mol Pharmacol. 2017 Jul;92(1):88-99. PMID: 28428226
Editor's Highlight: Spatiotemporal Progression and Remission of Lesions in the Rat Brain Following Acute Intoxication With Diisopropylfluorophosphate
Sisó S, Hobson BA, Harvey DJ, Bruun DA, Rowland DJ, Garbow JR, Lein PJ
Toxicol Sci. 2017 Jun 1;157(2):330-341. PMID: 28329845
From the Cover: Magnetic Resonance Imaging Reveals Progressive Brain Injury in Rats Acutely Intoxicated With Diisopropylfluorophosphate
Hobson BA, Sisó S, Rowland DJ, Harvey DJ, Bruun DA, Garbow JR, Lein PJ
Toxicol Sci. 2017 Jun 1;157(2):342-353. PMID: 28329842
Hydroxy-fipronil is a new urinary biomarker of exposure to fipronil
Vasylieva N, Barnych B, Wan D, El-Sheikh EA, Nguyen HM, Wulff H, McMahen R, Strynar M, Gee SJ, Hammock BD
Environ Int. 2017 Jun;103:91-98. doi: 10.1016/j.envint.2017.03.012. Epub 2017 Mar 23. PMID: 28343720
Soluble epoxide hydrolase as a therapeutic target for pain, inflammatory and neurodegenerative diseases
Wagner KM, McReynolds CB, Schmidt WK, Hammock BD
Pharmacol Ther. 2017 Jun 19. pii: S0163-7258(17)30154-7. PMID: 28642117 [
Soluble epoxide hydrolase inhibition alleviates neuropathy in Akita (Ins2 Akita) mice
Wagner K, Gilda J, Yang J, Wan D, Morisseau C, Gomes AV, Hammock BD
Behav Brain Res. 2017 May 30;326:69-76. PMID: 28259677
Synthesis of cyclooxygenase metabolites of 8,9-epoxyeicosatrienoic acid (EET): 11- and 15-hydroxy 8,9-EETs
Barnych B, Rand AA, Cajka T, Lee KSS, Hammock BD
Org Biomol Chem. 2017 May 23;15(20):4308-4313. PMID: 28470279
Sensitive immunoassay for detection and quantification of the neurotoxin, tetramethylenedisulfotetramine
Vasylieva N, Barnych B, Rand A, Inceoglu B, Gee SJ, Hammock BD
Analytical chemistry. 2017 May 16;89(10):5612-5619. PMID: 28398746; PMCID: PMC5920647.
Structural insights into the atomistic mechanisms of action of small molecule inhibitors targeting the KCa3.1 channel pore
Nguyen HM, Singh V, Pressly B, Jenkins DP, Wulff H, Yarov-Yarovoy V
Mol Pharmacol. 2017 Apr;91(4):392-402. PMID: 28126850
Nanostructure introduces artifacts in quantitative immunofluorescence by influencing fluorophore intensity
Chapman CA, Zhu X, Chen H, Yanik AA, Lein PJ, Seker E
Sci Rep. 2017 Mar 27;7(1):427. PMID: 28348397
Epoxy fatty acids mediate analgesia in murine diabetic neuropathy
Wagner K, Lee KS, Yang J, Hammock BD
Eur J Pain. 2017 Mar;21(3):456-465. PMID: 27634339
Inhibition of soluble epoxide hydrolase augments astrocyte release of vascular endothelial growth factor and neuronal recovery after oxygen-glucose deprivation
Zhang Y, Hong G, Lee KS, Hammock BD, Gebremedhin D, Harder DR, Koehler RC, Sapirstein A
J Neurochem. 2017 Mar;140(5):814-825. PMID: 28002622
Chemical synthesis and biological evaluation of ω-hydroxy polyunsaturated fatty acids
Hwang SH, Wagner K, Xu J, Yang J, Li X, Cao Z, Morisseau C, Lee KS, Hammock BD
Bioorg Med Chem Lett. 2017 Feb 1;27(3):620-625. PMID: 28025003
Influence of tetramethylenedisulfotetramine on synchronous calcium oscillations at distinct developmental stages of hippocampal neuronal cultures
Cao Z, Xu J, Hulsizer S, Cui Y, Dong Y, Pessah IN
Neurotoxicology. 2017 Jan;58:11-22. PMID: 27984050
Nanoporous gold biointerfaces: modifying nanostructure to control neural cell coverage and enhance electrophysiological recording performance
Chapman CAR, Wang L, Chen H, Garrison J, Lein PJ, Seker E
Adv Funct Mater. 2017 Jan 19;27(3). pii: 1604631. PMID: 28626362
Probing the orientation of inhibitor and epoxy-eicosatrienoic acid binding in the active site of soluble epoxide hydrolase
Lee KS, Henriksen NM, Ng CJ, Yang J, Jia W, Morisseau C, Andaya A, Gilson MK, Hammock BD
Arch Biochem Biophys. 2017 Jan 1;613:1-11. PMID: 27983948
Persistent neuroinflammation and cognitive impairment in a rat model of acute diisopropylfluorophosphate intoxication
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J Neuroinflammation. 2016 Oct 12;13(1):267. PMID: 27733171
VHH antibodies: emerging reagents for the analysis of environmental chemicals
Bever CS, Dong JX, Vasylieva N, Barnych B, Cui Y, Xu ZL, Hammock BD, Gee SJ
Anal Bioanal Chem. 2016 Sep;408(22):5985-6002. PMID: 27209591
Mechanisms of reduced astrocyte surface coverage in cortical neuron-glia co-cultures on nanoporous gold surfaces
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Cell Mol Bioeng. 2016 Sep;9(3):433-442. PMID: 27795742
Models to identify treatments for the acute and persistent effects of seizure-inducing chemical threat agents
Pessah IN, Rogawski MA, Tancredi DJ, Wulff H, Zolkowska D, Bruun DA, Hammock BD, Lein PJ
Ann N Y Acad Sci. 2016 Aug;1378(1):124-136. PMID: 27467073
Inhibition of soluble epoxide hydrolase as a novel approach to high dose diazepam induced hypotension
Ulu A, Inceoglu B, Yang J, Singh V, Vito S, Wulff H, Hammock BD
J Clin Toxicol. 2016 Jun;6(3). pii: 1000300. PMID: 28255523
Novel omega-3 fatty acid epoxygenase metabolite reduces kidney fibrosis
Sharma A, Hye Khan MA, Levick SP, Lee KS, Hammock BD, Imig JD
Int J Mol Sci. 2016 May 18;17(5). pii: E751. PMID: 27213332
Dietary linoleic acid-induced alterations in pro- and anti-nociceptive lipid autacoids: Implications for idiopathic pain syndromes?
Ramsden CE, Ringel A, Majchrzak-Hong SF, Yang J, Blanchard H, Zamora D, Loewke JD, Rapoport SI, Hibbeln JR, Davis JM, Hammock BD, Taha AY
Mol Pain. 2016 Mar 10;12. pii: 1744806916636386. PMID: 27030719
Pro-atherogenic role of smooth muscle Nox4-based NADPH oxidase
Tong X, Khandelwal AR, Wu X, Xu Z, Yu W, Chen C, Zhao W, Yang J, Qin Z, Weisbrod RM, Seta F, Ago T, Lee KS, Hammock BD, Sadoshima J,, Cohen RA, Zeng C
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Recent developments in ion channel pharmacology
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Channels (Austin). 2015;9(6):335. PMID: 26646476
Contrasting actions of a convulsant barbiturate and its anticonvulsant enantiomer on the α1 β3 γ2L GABAA receptor account for their in vivo effects
Desai R, Savechenkov PY, Zolkowska D, Ge RL, Rogawski MA, Bruzik KS, Forman SA, Raines DE, Miller KW
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Combined treatment with diazepam and allopregnanolone reverses tetramethylenedisulfotetramine (TETS)-induced calcium dysregulation in cultured neurons and protects TETS-intoxicated mice against lethal seizures
Bruun DA, Cao Z, Inceoglu B, Vito ST, Austin AT, Hulsizer S, Hammock BD, Tancredi DJ, Rogawski MA, Pessah IN, Lein PJ
Neuropharmacology. 2015 Aug;95:332-42. PMID: 25882826
Development of an immunoassay for the detection of the phenylpyrazole insecticide fipronil
Vasylieva N, Ahn KC, Barnych B, Gee SJ, Hammock BD.
Environ Sci Technol. 2015 Aug 18;49(16):10038-47. PMID: 26196357
Endoplasmic reticulum stress in the peripheral nervous system is a significant driver of neuropathic pain
Inceoglu B, Bettaieb A, Trindade da Silva CA, Lee KS, Haj FG, Hammock BD
Proc Natl Acad Sci U S A. 2015 Jul 21;112(29):9082-7. PMID: 26150506
The Alzheimer's Disease Neuroimaging Initiative phase 2: Increasing the length, breadth, and depth of our understanding
Beckett LA, Donohue MC, Wang C, Aisen P, Harvey DJ, Saito N; Alzheimer's Disease Neuroimaging Initiative.
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Peripheral FAAH and soluble epoxide hydrolase inhibitors are synergistically antinociceptive
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Pharmacological gating modulation of small- and intermediate-conductance Ca(2+)-activated K(+) channels (KCa2.x and KCa3.1)
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High salt intake increases blood pressure in normal rats: putative role of 20-HETE and no evidence on changes in renal vascular reactivity
Walkowska A, Kuczeriszka M, Sadowski J, Olszyñski KH, Dobrowolski L, Červenka L, Hammock BD, Kompanowska-Jezierska E
Kidney Blood Press Res. 2015;40(3):323-34. PMID: 26067851
Rapid throughput analysis demonstrates that chemicals with distinct seizurogenic mechanisms differentially alter Ca2+ dynamics in networks formed by hippocampal neurons in culture
Cao Z, Zou X, Cui Y, Hulsizer S, Lein PJ, Wulff H, Pessah IN
Mol Pharmacol. 2015 Apr;87(4):595-605. doi: 10.1124/mol.114.096701. Epub 2015 Jan 12.
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ACS Appl Mater Interfaces. 2015 Apr 8;7(13):7093-100. PMID: 25706691
Neuregulin-1 inhibits neuroinflammatory responses in a rat model of organophosphate-nerve agent-induced delayed neuronal injury
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J Neuroinflammation. 2015 Apr 2;12:64. PMID: 25880399
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Rogawski MA, Tofighy A, White HS, Matagne A, Wolff C
Epilepsy Res. 2015 Feb;110:189-205. PMID: 25616473
Potent natural soluble epoxide hydrolase inhibitors from Pentadiplandra brazzeana baillon: synthesis, quantification, and measurement of biological activities in vitro and in vivo
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PLoS One. 2015 Feb 6;10(2):e0117438. PMID: 25659109
PPARδ signaling mediates the cytotoxicity of DHA in H9c2 cells
Samokhvalov V, Zlobine I, Jamieson KL, Jurasz P, Chen C, Lee KS, Hammock BD, Seubert JM
Toxicol Lett. 2015 Jan 5;232(1):10-20. PMID: 25300478
The riluzole derivative 2-amino-6-trifluoromethylthio-benzothiazole (SKA-19), a mixed KCa2 activator and NaV blocker, is a potent novel anticonvulsant
Coleman N, Nguyen HM, Cao Z, Brown BM, Jenkins DP, Zolkowska D, Chen YJ, Tanaka BS, Goldin AL, Rogawski MA, Pessah IN, Wulff H
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Curr Neurobiol. 2014 Dec 1;5(1-2):1-10. PMID: 25705100
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Toxicol Appl Pharmacol. 2014 Dec 1;281(2):185-94. PMID: 25448683
The role of long chain fatty acids and their epoxide metabolites in nociceptive signaling
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Prostaglandins Other Lipid Mediat. 2014 Oct;113-115:2-12. PMID: 25240260
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Nanomolar bifenthrin alters synchronous Ca2+ oscillations and cortical neuron development independent of sodium channel activity
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Mol Pharmacol. 2014 Apr;85(4):630-9. PMID: 24482397
The potential of antiseizure drugs and agents that act on novel molecular targets as antiepileptogenic treatments
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Neurotherapeutics. 2014 Apr;11(2):385-400. PMID: 24671870
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Am J Physiol Heart Circ Physiol. 2013 Dec 1;305(11):H1605-13. PMID: 24043255
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Isolation of alpaca anti-idiotypic heavy-chain single-domain antibody for the aflatoxin immunoassay
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Synthesis and biological evaluation of sorafenib- and regorafenib-like sEH inhibitors
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Therapeutic activity of inhibition of the soluble epoxide hydrolase in a mouse model of scrapie
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Phage-displayed peptide that mimics aflatoxins and its application in immunoassay
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J Agric Food Chem. 2013 Mar 13;61(10):2426-33. PMID: 23394544
Rationally designed multitarget agents against inflammation and pain
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AMPA receptors as a molecular target in epilepsy therapy
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Acta Neurol Scand Suppl. 2013;(197):9-18. PMID: 23480151
Preclinical pharmacology of perampanel, a selective non-competitive AMPA receptor antagonist
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Tetramethylenedisulfotetramine alters Ca²⁺ dynamics in cultured hippocampal neurons: mitigation by NMDA receptor blockade and GABA(A) receptor-positive modulation
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Importance of membrane selection in the development of immunochromatographic assays for low-molecular weight compounds
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Neuregulin-1 is neuroprotective in a rat model of organophosphate-induced delayed neuronal injury
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