Publications

Publications

Pharmacology of small- and intermediate-conductance calcium-activated potassium channels
Brown BM, Shim H, Christophersen P, Wulff H
Annu Rev Pharmacol Toxicol. 2020;60:219-240.

PMID 31337271

Susceptibility of larval zebrafish to the seizurogenic activity of GABA type A receptor antagonists
Bandara SB, Carty DR, Singh V, Harvey DJ, Vasylieva N, Pressly B, Wulff H, Lein PJ
Neurotoxicology. 2020 Jan;76:220-234. doi: 10.1016/j.neuro.2019.12.001. Epub 2019 Dec 4.
PMID: 31811871

Persistent behavioral deficits, neuroinflammation and oxidative stress in a rat model of acute organophosphate intoxication
Guignet M, Dhakal K, Flannery BM, Hobson BA, Zolkowska D, Dhir A, Bruun DA, Li S, Harvey DJ, Silverman JL, Rogawski MA, Lein PJ
Neurobiol Dis. 2020 Jan;133:104431.
PubMed PMID: 30905768; PMCID: PMC6754818

-- 2019 --

Lipidomes of brain from rats acutely intoxicated with diisopropylfluorophosphate identifies potential therapeutic targets
Yang J, Bruun DA, Wang C, Wan D, McReynolds CB, Phu K, Inceoglu B, Lein PJ, Hammock BD
Toxicol Appl Pharmacol. 2019 Nov 1;382:114749. doi: 10.1016/j.taap.2019.114749. Epub 2019 Sep 12. PMID: 31521729

Pretreatment with pyridostigmine bromide has no effect on seizure behavior or 24 hour survival in the rat model of acute diisopropylfluorophosphate intoxication
Bruun DA, Guignet M, Harvey DJ, Lein PJ
Neurotoxicology. 2019 Jul;73:81-84.
PubMed PMID: 30853371; PMCID: PMC66344995

TSPO PET using [18F]PBR111 reveals persistent neuroinflammation following acute diisopropylfluorophosphate intoxication in the rat.
Hobson BA, Rowland DJ, Siso S, Guignet MA, Harmany ZT, Bandara S, Saito N, Harvey DJ, Bruun DA, Garbow JR, Chaudhari AF, Lein PJ Toxicol Sci. 2019: 170(2):330-344. PMC6657665

Organophosphates
Guignet M, Lein PJ
In: Advances in Neurotoxicology: Role of Inflammation in Environmental Neurotoxicity, volume 3 (Edited by M Aschner, LG Costa), Academic Press, Cambridge, MA, pp. 35-79. 2019

The use of percent change in RR interval for data exclusion in analyzing 24 hour time domain heart rate variability in rats
Karey E, Pan S, Morris A, Bruun DA, Lein PJ, Chen CY
Front. Physiol., 2019 Jun;10:693.
PubMed PMID: 31244671; PMCID: PMC6562196

Antibodies and venom peptides: new modalities for ion channels
Wulff H, Christophersen P, Colussi P, Chandy KG, Yarov-Yarovoy V
Nat Rev Drug Discov. 2019 May;18(5):339-357. doi: 10.1038/s41573-019-0013-8.
PubMed PMID: 30728472; PMCID: PMC6499689

The pharmacokinetics of ketamine following intramuscular injection to F344 rats
Moeller B, Espelien B, Weber W, Kuehl P, Doyle-Eisele M, Garner CE, McDonald JD, Garcia E, Raulli R, Laney J
Drug Test Anal.2019 Jan;11(1):68-76. doi: 10.1002/dta.2468. Epub 2018 Aug 14.
PubMed PMID: 30027605; PMCID: .PMC6538562

1-Trifluoromethoxyphenyl-3-(1-propionylpiperidin-4-yl) urea, a selective and potent dual inhibitor of soluble epoxide hydrolase and p38 kinase intervenes in Alzheimer's signaling in human nerve cells
Liang Z, Zhang B, Xu M, Morisseau C, Hwang SH, Hammock BD, Li QX
ACS Chem Neurosci. 2019;10:4018-4030. PMC 7028313

Acute peripheral immune activation alters cytokine expression and glial activation in the early postnatal rat brain
Bruce M, Streifel KM, Boosalis CA, Heuer L, González EA, Li S, Harvey DJ, Lein PJ, Van de Water J
J Neuroinflammation. 2019 Oct 31;16(1):200. PubMed PMID: 31672161; PubMed Central PMCID: PMC6822372.

-- 2018 --

Bifenthrin causes transcriptomic alterations in mTOR and ryanodine receptor-dependent signaling and delayed hyperactivity in developing zebrafish (Danio rerio)
Frank DF, Miller GW, Harvey DJ, Brander SM, Geist J, Connon RE, Lein PJ
Aquat Toxicol. 2018 Jul;200:50-61. doi: 10.1016/j.aquatox.2018.04.003. Epub 2018 Apr 18.
PMID: 29727771

A Microfluidic Platform to Study Astrocyte Adhesion on Nanoporous Gold Thin Films
Hampe AE, Li Z, Sethi S, Lein PJ, Seker E
Nanomaterials (Basel, Switzerland). 2018 June 21;8(7).
PubMed PMID: 29933551; PubMed Central PMCID: PMC6070884.

Determination of minimal steady-state plasma level of diazepam causing seizure threshold elevation in rats
Dhir A, Rogawski MA
Epilepsia.2018 May;59(5):935-944. doi: 10.1111/epi.14069. Epub 2018 Apr 6.
PubMed PMID: 29682729; PMCID: PMC5934328

A magnetic resonance imaging study of early brain injury in a rat model of acute DFP intoxication
Hobson BA, Rowland DJ, Supasai S, Harvey DJ, Lein PJ, Garbow JR
Neurotoxicology. 2018 May;66:170-178. doi: 10.1016/j.neuro.2017.11.009. Epub 2017 Nov 26.
PubMed PMID: 29183789; PMCID: PMC5940565

Soluble epoxide hydrolase inhibition decreases reperfusion injury after focal cerebral ischemia
Tu R, Armstrong J, Lee KSS, Hammock BD, Sapirstein A, Koehler RC
Scientific Reports. 2018 March 27;8(1):5279.
PubMed PMID: 29588470; PubMed Central PMCID: PMC5869703

COX-2/sEH Dual Inhibitor PTUPB Potentiates the Antitumor Efficacy of Cisplatin
Wang F, Zhang H, Ma AH, Yu W, Zimmermann M, Yang J, Hwang SH, Zhu D, Lin TY, Malfatti M, Turteltaub KW, Henderson PT, Airhart S, Hammock BD, Yuan J, de Vere White RW, Pan CX
Molecular cancer therapeutics. 2018 February;17(2):474-483.
PubMed PMID: 29284644; PubMed Central PMCID: PMC5824635.

GABAA receptor subtype selectivity of the proconvulsant rodenticide TETS
Pressly B, Nguyen HM, Wulff H
Arch Toxicol. 2018 Feb;92(2):833-844. doi: 10.1007/s00204-017-2089-4. Epub 2017 Oct 16.
PubMed PMID: 29038840

-- 2017 --

Structural Determinants for the Selectivity of the Positive KCa3.1 Gating Modulator 5-Methylnaphtho[2,1-d]oxazol-2-amine (SKA-121)
Brown BM, Shim H, Zhang M, Yarov-Yarovoy V, Wulff H
Mol Pharmacol. 2017 Oct;92(4):469-480. doi: 10.1124/mol.117.109421. Epub 2017 Jul 31.
PMID: 28760780

Rapid Throughput Analysis of GABAAReceptor Subtype Modulators and Blockers Using DiSBAC1(3) Membrane Potential Red Dye
Nik AM, Pressly B, Singh V, Antrobus S, Hulsizer S, Rogawski MA, Wulff H, Pessah IN
Mol Pharmacol. 2017 Jul;92(1):88-99. doi: 10.1124/mol.117.108563. Epub 2017 Apr 20.
PMID: 28428226

Editor's Highlight: Spatiotemporal Progression and Remission of Lesions in the Rat Brain Following Acute Intoxication With Diisopropylfluorophosphate
Sisó S, Hobson BA, Harvey DJ, Bruun DA, Rowland DJ, Garbow JR, Lein PJ
Toxicol Sci. 2017 Jun 1;157(2):330-341. doi: 10.1093/toxsci/kfx048.
PMID: 28329845

From the Cover: Magnetic Resonance Imaging Reveals Progressive Brain Injury in Rats Acutely Intoxicated With Diisopropylfluorophosphate
Hobson BA, Sisó S, Rowland DJ, Harvey DJ, Bruun DA, Garbow JR, Lein PJ
Toxicol Sci. 2017 Jun 1;157(2):342-353. doi: 10.1093/toxsci/kfx049.
PMID: 28329842

Hydroxy-fipronil is a new urinary biomarker of exposure to fipronil
Vasylieva N, Barnych B, Wan D, El-Sheikh EA, Nguyen HM, Wulff H, McMahen R, Strynar M, Gee SJ, Hammock BD
Environ Int. 2017 Jun;103:91-98. doi: 10.1016/j.envint.2017.03.012. Epub 2017 Mar 23.
PMID: 28343720 [PubMed - in process]

Soluble epoxide hydrolase as a therapeutic target for pain, inflammatory and neurodegenerative diseases
Wagner KM, McReynolds CB, Schmidt WK, Hammock BD
Pharmacol Ther. 2017 Jun 19. pii: S0163-7258(17)30154-7. doi: 10.1016/j.pharmthera.2017.06.006. [Epub ahead of print] Review.
PMID: 28642117 [PubMed - as supplied by publisher]

Sensitive immunoassay for detection and quantification of the neurotoxin, tetramethylenedisulfotetramine
Vasylieva N, Barnych B, Rand A, Inceoglu B, Gee SJ, Hammock BD
Analytical chemistry. 2017 May 16;89(10):5612-5619.
PubMed PMID: 28398746; PubMed Central PMCID: PMC5920647.

Soluble epoxide hydrolase inhibition alleviates neuropathy in Akita (Ins2 Akita) mice
Wagner K, Gilda J, Yang J, Wan D, Morisseau C, Gomes AV, Hammock BD
Behav Brain Res. 2017 May 30;326:69-76. doi: 10.1016/j.bbr.2017.02.048. Epub 2017 Mar 1.
PMID: 28259677 [PubMed - in process]

Synthesis of cyclooxygenase metabolites of 8,9-epoxyeicosatrienoic acid (EET): 11- and 15-hydroxy 8,9-EETs
Barnych B, Rand AA, Cajka T, Lee KSS, Hammock BD
Org Biomol Chem. 2017 May 23;15(20):4308-4313. doi: 10.1039/c7ob00789b.
PMID: 28470279 [PubMed - in process]

Structural insights into the atomistic mechanisms of action of small molecule inhibitors targeting the KCa3.1 channel pore
Nguyen HM, Singh V, Pressly B, Jenkins DP, Wulff H, Yarov-Yarovoy V
Mol Pharmacol. 2017 Apr;91(4):392-402. doi: 10.1124/mol.116.108068. Epub 2017 Jan 26.
PMID: 28126850 [PubMed - indexed for MEDLINE]

Nanostructure introduces artifacts in quantitative immunofluorescence by influencing fluorophore intensity
Chapman CA, Zhu X, Chen H, Yanik AA, Lein PJ, Seker E
Sci Rep. 2017 Mar 27;7(1):427. doi: 10.1038/s41598-017-00447-7.
PMID: 28348397 [PubMed - in process]

Epoxy fatty acids mediate analgesia in murine diabetic neuropathy
Wagner K, Lee KS, Yang J, Hammock BD
Eur J Pain. 2017 Mar;21(3):456-465. doi: 10.1002/ejp.939. Epub 2016 Sep 15.
PMID: 27634339 [PubMed - in process]

Inhibition of soluble epoxide hydrolase augments astrocyte release of vascular endothelial growth factor and neuronal recovery after oxygen-glucose deprivation
Zhang Y, Hong G, Lee KS, Hammock BD, Gebremedhin D, Harder DR, Koehler RC, Sapirstein A
J Neurochem. 2017 Mar;140(5):814-825. doi: 10.1111/jnc.13933. Epub 2017 Jan 23.
PMID: 28002622 [PubMed - indexed for MEDLINE]

Chemical synthesis and biological evaluation of ω-hydroxy polyunsaturated fatty acids
Hwang SH, Wagner K, Xu J, Yang J, Li X, Cao Z, Morisseau C, Lee KS, Hammock BD
Bioorg Med Chem Lett. 2017 Feb 1;27(3):620-625. doi: 10.1016/j.bmcl.2016.12.002. Epub 2016 Dec 2.
PMID: 28025003 [PubMed - indexed for MEDLINE]

Influence of tetramethylenedisulfotetramine on synchronous calcium oscillations at distinct developmental stages of hippocampal neuronal cultures
Cao Z, Xu J, Hulsizer S, Cui Y, Dong Y, Pessah IN
Neurotoxicology. 2017 Jan;58:11-22. doi: 10.1016/j.neuro.2016.10.015. Epub 2016 Oct 29.
PMID: 27984050 [PubMed - in process]

Probing the orientation of inhibitor and epoxy-eicosatrienoic acid binding in the active site of soluble epoxide hydrolase
Lee KS, Henriksen NM, Ng CJ, Yang J, Jia W, Morisseau C, Andaya A, Gilson MK, Hammock BD
Arch Biochem Biophys. 2017 Jan 1;613:1-11. doi: 10.1016/j.abb.2016.10.017. Epub 2016 Oct 29.
PMID: 27983948 [PubMed - indexed for MEDLINE]

Nanoporous gold biointerfaces: modifying nanostructure to control neural cell coverage and enhance electrophysiological recording performance
Chapman CAR, Wang L, Chen H, Garrison J, Lein PJ, Seker E
Adv Funct Mater. 2017 Jan 19;27(3). pii: 1604631. doi: 10.1002/adfm.201604631. Epub 2016 Dec 12.
PMID: 28626362 [PubMed]

-- 2016 --

Persistent neuroinflammation and cognitive impairment in a rat model of acute diisopropylfluorophosphate intoxication
Flannery BM, Bruun DA, Rowland DJ, Banks CN, Austin AT, Kukis DL, Li Y, Ford BD, Tancredi DJ, Silverman JL, Cherry SR, Lein PJ
J Neuroinflammation. 2016 Oct 12;13(1):267.
PMID: 27733171 [PubMed - in process]

VHH antibodies: emerging reagents for the analysis of environmental chemicals
Bever CS, Dong JX, Vasylieva N, Barnych B, Cui Y, Xu ZL, Hammock BD, Gee SJ
Anal Bioanal Chem. 2016 Sep;408(22):5985-6002. doi: 10.1007/s00216-016-9585-x. Epub 2016 May 21. Review.
PMID: 27209591 [PubMed - in process]

Mechanisms of reduced astrocyte surface coverage in cortical neuron-glia co-cultures on nanoporous gold surfaces
Chapman CA, Chen H, Stamou M, Lein PJ, Seker E
Cell Mol Bioeng. 2016 Sep;9(3):433-442. Epub 2016 May 31.
PMID: 27795742 [PubMed]

Models to identify treatments for the acute and persistent effects of seizure-inducing chemical threat agents
Pessah IN, Rogawski MA, Tancredi DJ, Wulff H, Zolkowska D, Bruun DA, Hammock BD, Lein PJ
Ann N Y Acad Sci. 2016 Aug;1378(1):124-136. doi: 10.1111/nyas.13137. Epub 2016 Jul 28. Review.
PMID: 27467073 [PubMed - indexed for MEDLINE]

Inhibition of soluble epoxide hydrolase as a novel approach to high dose diazepam induced hypotension
Ulu A, Inceoglu B, Yang J, Singh V, Vito S, Wulff H, Hammock BD
J Clin Toxicol. 2016 Jun;6(3). pii: 1000300. doi: 10.4172/2161-0495.1000300. Epub 2016 May 30.
PMID: 28255523 [PubMed]

Novel omega-3 fatty acid epoxygenase metabolite reduces kidney fibrosis
Sharma A, Hye Khan MA, Levick SP, Lee KS, Hammock BD, Imig JD
Int J Mol Sci. 2016 May 18;17(5). pii: E751. doi: 10.3390/ijms17050751.
PMID: 27213332 [PubMed - indexed for MEDLINE]

Dietary linoleic acid-induced alterations in pro- and anti-nociceptive lipid autacoids: Implications for idiopathic pain syndromes?
Ramsden CE, Ringel A, Majchrzak-Hong SF, Yang J, Blanchard H, Zamora D, Loewke JD, Rapoport SI, Hibbeln JR, Davis JM, Hammock BD, Taha AY
Mol Pain. 2016 Mar 10;12. pii: 1744806916636386. doi: 10.1177/1744806916636386. Print 2016.
PMID: 27030719 [PubMed - indexed for MEDLINE]

Pro-atherogenic role of smooth muscle Nox4-based NADPH oxidase
Tong X, Khandelwal AR, Wu X, Xu Z, Yu W, Chen C, Zhao W, Yang J, Qin Z, Weisbrod RM, Seta F, Ago T, Lee KS, Hammock BD, Sadoshima J,, Cohen RA, Zeng C
J Mol Cell Cardiol. 2016 Mar;92:30-40. doi: 10.1016/j.yjmcc.2016.01.020. Epub 2016 Jan 23.
PMID: 26812119 [PubMed - indexed for MEDLINE]

-- 2015 --

Recent developments in ion channel pharmacology
Wulff H, Christophersen P
Channels (Austin). 2015;9(6):335. doi: 10.1080/19336950.2015.1077650. Epub 2015 Nov 17. No abstract available.\
PMID: 26646476 [PubMed - indexed for MEDLINE]

Contrasting actions of a convulsant barbiturate and its anticonvulsant enantiomer on the α1 β3 γ2L GABAA receptor account for their in vivo effects
Desai R, Savechenkov PY, Zolkowska D, Ge RL, Rogawski MA, Bruzik KS, Forman SA, Raines DE, Miller KW
J Physiol. 2015 Nov 15;593(22):4943-61. doi: 10.1113/JP270971.
PMID: 26378885 [PubMed - indexed for MEDLINE]

Combined treatment with diazepam and allopregnanolone reverses tetramethylenedisulfotetramine (TETS)-induced calcium dysregulation in cultured neurons and protects TETS-intoxicated mice against lethal seizures
Bruun DA, Cao Z, Inceoglu B, Vito ST, Austin AT, Hulsizer S, Hammock BD, Tancredi DJ, Rogawski MA, Pessah IN, Lein PJ
Neuropharmacology. 2015 Aug;95:332-42. doi: 10.1016/j.neuropharm.2015.03.035. Epub 2015 Apr 14. PMID: 25882826

Development of an immunoassay for the detection of the phenylpyrazole insecticide fipronil
Vasylieva N, Ahn KC, Barnych B, Gee SJ, Hammock BD.
Environ Sci Technol. 2015 Aug 18;49(16):10038-47. doi: 10.1021/acs.est.5b01005. Epub 2015 Aug 5.
PMID: 26196357 [PubMed - indexed for MEDLINE]

Endoplasmic reticulum stress in the peripheral nervous system is a significant driver of neuropathic pain
Inceoglu B, Bettaieb A, Trindade da Silva CA, Lee KS, Haj FG, Hammock BD
Proc Natl Acad Sci U S A. 2015 Jul 21;112(29):9082-7. doi: 10.1073/pnas.1510137112. Epub 2015 Jul 6.
PMID: 26150506 [PubMed - indexed for MEDLINE]

The Alzheimer's Disease Neuroimaging Initiative phase 2: Increasing the length, breadth, and depth of our understanding
Beckett LA, Donohue MC, Wang C, Aisen P, Harvey DJ, Saito N; Alzheimer's Disease Neuroimaging Initiative.
Alzheimers Dement. 2015 Jul;11(7):823-31. doi: 10.1016/j.jalz.2015.05.004. Review.
PMID: 26194315 [PubMed - indexed for MEDLINE]

Peripheral FAAH and soluble epoxide hydrolase inhibitors are synergistically antinociceptive
Sasso O, Wagner K, Morisseau C, Inceoglu B, Hammock BD, Piomelli D
Pharmacol Res. 2015 Jul;97:7-15. doi: 10.1016/j.phrs.2015.04.001. Epub 2015 Apr 14.
PMID: 25882247 [PubMed - indexed for MEDLINE]

Pharmacological gating modulation of small- and intermediate-conductance Ca(2+)-activated K(+) channels (KCa2.x and KCa3.1)
Christophersen P, Wulff H
Channels (Austin). 2015;9(6):336-43. doi: 10.1080/19336950.2015.1071748. Epub 2015 Jul 28. Review.
PMID: 26217968 [PubMed - indexed for MEDLINE]

High salt intake increases blood pressure in normal rats: putative role of 20-HETE and no evidence on changes in renal vascular reactivity
Walkowska A, Kuczeriszka M, Sadowski J, Olszyñski KH, Dobrowolski L, Červenka L, Hammock BD, Kompanowska-Jezierska E
Kidney Blood Press Res. 2015;40(3):323-34. doi: 10.1159/000368508. Epub 2015 May 31.
PMID: 26067851 [PubMed - indexed for MEDLINE]

Rapid throughput analysis demonstrates that chemicals with distinct seizurogenic mechanisms differentially alter Ca2+ dynamics in networks formed by hippocampal neurons in culture
Cao Z, Zou X, Cui Y, Hulsizer S, Lein PJ, Wulff H, Pessah IN
Mol Pharmacol. 2015 Apr;87(4):595-605. doi: 10.1124/mol.114.096701. Epub 2015 Jan 12.
PMID: 25583085 [PubMed - indexed for MEDLINE]

Nanoporous gold as a neural interface coating: effects of topography, surface chemistry, and feature size
Chapman CA, Chen H, Stamou M, Biener J, Biener MM, Lein PJ, Seker E
ACS Appl Mater Interfaces. 2015 Apr 8;7(13):7093-100. doi: 10.1021/acsami.5b00410. Epub 2015 Mar 2.
PMID: 25706691 [PubMed - indexed for MEDLINE]

Neuregulin-1 inhibits neuroinflammatory responses in a rat model of organophosphate-nerve agent-induced delayed neuronal injury
Li Y, Lein PJ, Ford GD, Liu C, Stovall KC, White TE, Bruun DA, Tewolde T, Gates AS, Distel TJ, Surles-Zeigler MC, Ford BD
J Neuroinflammation. 2015 Apr 2;12:64. doi: 10.1186/s12974-015-0283-y.
PMID: 25880399 [PubMed - indexed for MEDLINE]

Current understanding of the mechanism of action of the antiepileptic drug lacosamide
Rogawski MA, Tofighy A, White HS, Matagne A, Wolff C
Epilepsy Res. 2015 Feb;110:189-205. doi: 10.1016/j.eplepsyres.2014.11.021. Epub 2014 Dec 3. Review.
PMID: 25616473 [PubMed - indexed for MEDLINE]

Potent natural soluble epoxide hydrolase inhibitors from Pentadiplandra brazzeana baillon: synthesis, quantification, and measurement of biological activities in vitro and in vivo
Kitamura S, Morisseau C, Inceoglu B, Kamita SG, De Nicola GR, Nyegue M, Hammock BD
PLoS One. 2015 Feb 6;10(2):e0117438. doi: 10.1371/journal.pone.0117438. eCollection 2015.
PMID: 25659109 [PubMed - indexed for MEDLINE]

PPARδ signaling mediates the cytotoxicity of DHA in H9c2 cells
Samokhvalov V, Zlobine I, Jamieson KL, Jurasz P, Chen C, Lee KS, Hammock BD, Seubert JM
Toxicol Lett. 2015 Jan 5;232(1):10-20. doi: 10.1016/j.toxlet.2014.09.029. Epub 2014 Oct 6.
PMID: 25300478 [PubMed - indexed for MEDLINE]

The riluzole derivative 2-amino-6-trifluoromethylthio-benzothiazole (SKA-19), a mixed KCa2 activator and NaV blocker, is a potent novel anticonvulsant
Coleman N, Nguyen HM, Cao Z, Brown BM, Jenkins DP, Zolkowska D, Chen YJ, Tanaka BS, Goldin AL, Rogawski MA, Pessah IN, Wulff H
Neurotherapeutics. 2015 Jan;12(1):234-49. doi: 10.1007/s13311-014-0305-y.
PMID: 25256961 [PubMed - indexed for MEDLINE]

Behavioral assessment of NIH Swiss mice acutely intoxicated with tetramethylenedisulfotetramine
Flannery BM, Silverman JL, Bruun DA, Puhger KR, McCoy MR, Hammock BD, Crawley JN, Lein PJ
Neurotoxicol Teratol. 2015 Jan-Feb;47:36-45. doi: 10.1016/j.ntt.2014.10.008. Epub 2014 Nov 8.
PMID: 25446016 [PubMed - indexed for MEDLINE]

-- 2014 --

Factors influencing adverse skin responses in rats receiving repeated subcutaneous injections and potential impact on neurobehavior
Levoe SN, Flannery BM, Brignolo L, Imai DM, Koehne A, Austin AT, Bruun DA, Tancredi DJ, Lein PJ
Curr Neurobiol. 2014 Dec 1;5(1-2):1-10.
PMID: 25705100 [PubMed]

Pediatric super-refractory status epilepticus treated with allopregnanolone
Broomall E, Natale JE, Grimason M, Goldstein J, Smith CM, Chang C, Kanes S, Rogawski MA, Wainwright MS
Ann Neurol. 2014 Dec;76(6):911-5. doi: 10.1002/ana.24295. Epub 2014 Nov 11.
PMID: 25363147 [PubMed - indexed for MEDLINE]

Post-exposure administration of diazepam combined with soluble epoxide hydrolase inhibition stops seizures and modulates neuroinflammation in a murine model of acute TETS intoxication
Vito ST, Austin AT, Banks CN, Inceoglu B, Bruun DA, Zolkowska D, Tancredi DJ, Rogawski MA, Hammock BD, Lein PJ
Toxicol Appl Pharmacol. 2014 Dec 1;281(2):185-94. doi: 10.1016/j.taap.2014.10.001. Epub 2014 Oct 14.
PMID: 25448683 [PubMed - indexed for MEDLINE]

The role of long chain fatty acids and their epoxide metabolites in nociceptive signaling
Wagner K, Vito S, Inceoglu B, Hammock BD
Prostaglandins Other Lipid Mediat. 2014 Oct;113-115:2-12. doi: 10.1016/j.prostaglandins.2014.09.001. Epub 2014 Sep 18. Review.
PMID: 25240260 [PubMed - indexed for MEDLINE]

Anticonvulsant potencies of the enantiomers of the neurosteroids androsterone and etiocholanolone exceed those of the natural forms
Zolkowska D, Dhir A, Krishnan K, Covey DF, Rogawski MA
Psychopharmacology (Berl). 2014 Sep;231(17):3325-32. doi: 10.1007/s00213-014-3546-x. Epub 2014 Apr 5.
PMID: 24705905 [PubMed - indexed for MEDLINE]

New positive Ca2+-activated K+ channel gating modulators with selectivity for KCa3.1
Coleman N, Brown BM, Oliván-Viguera A, Singh V, Olmstead MM, Valero MS, Köhler R, Wulff H
Mol Pharmacol. 2014 Sep;86(3):342-57. doi: 10.1124/mol.114.093286. Epub 2014 Jun 23.
PMID: 24958817 [PubMed - indexed for MEDLINE]

Perampanel inhibition of AMPA receptor currents in cultured hippocampal neurons
Chen CY, Matt L, Hell JW, Rogawski MA
PLoS One. 2014 Sep 17;9(9):e108021. doi: 10.1371/journal.pone.0108021. eCollection 2014.
PMID: 25229608 [PubMed - indexed for MEDLINE]

Optimized inhibitors of soluble epoxide hydrolase improve in vitro target residence time and in vivo efficacy
Lee KS, Liu JY, Wagner KM, Pakhomova S, Dong H, Morisseau C, Fu SH, Yang J, Wang P, Ulu A, Mate CA, Nguyen LV, Hwang SH, Edin ML, Mara AA, Wulff H, Newcomer ME, Zeldin DC, Hammock BD
J Med Chem. 2014 Aug 28;57(16):7016-30. doi: 10.1021/jm500694p. Epub 2014 Aug 11.
PMID: 25079952 [PubMed - indexed for MEDLINE]

GABAA receptor target of tetramethylenedisulfotetramine
Zhao C, Hwang SH, Buchholz BA, Carpenter TS, Lightstone FC, Yang J, Hammock BD, Casida JE
Proc Natl Acad Sci U S A. 2014 Jun 10;111(23):8607-12. doi: 10.1073/pnas.1407379111. Epub 2014 May 27. Erratum in:\
Proc Natl Acad Sci U S A.2014 Jul 29;111(30):11223. Lightstone, Felice [corrected to Lightstone, Felice C].
PMID: 24912155 [PubMed - indexed for MEDLINE]

Nanomolar bifenthrin alters synchronous Ca2+ oscillations and cortical neuron development independent of sodium channel activity
Cao Z, Cui Y, Nguyen HM, Jenkins DP, Wulff H, Pessah IN
Mol Pharmacol. 2014 Apr;85(4):630-9. doi: 10.1124/mol.113.090076. Epub 2014 Jan 30.
PMID: 24482397 [PubMed - indexed for MEDLINE]

The potential of antiseizure drugs and agents that act on novel molecular targets as antiepileptogenic treatments
Kaminski RM, Rogawski MA, Klitgaard H
Neurotherapeutics. 2014 Apr;11(2):385-400. doi: 10.1007/s13311-014-0266-1. Review.
PMID: 24671870 [PubMed - indexed for MEDLINE]

Role of GluK1 kainate receptors in seizures, epileptic discharges, and epileptogenesis
Fritsch B, Reis J, Gasior M, Kaminski RM, Rogawski MA
J Neurosci. 2014 Apr 23;34(17):5765-75. doi: 10.1523/JNEUROSCI.5307-13.2014.
PMID: 24760837 [PubMed - indexed for MEDLINE]

Inhibition of soluble epoxide hydrolase is renoprotective in 5/6 nephrectomized Ren-2 transgenic hypertensive rats
Kujal P, Čertíková Chábová V, Škaroupková P, Husková Z, Vernerová Z, Kramer HJ, Walkowska A, Kompanowska-Jezierska E, Sadowski J, Kitada K, Nishiyama A, Hwang SH, Hammock BD, Imig JD, Červenka L
Clin Exp Pharmacol Physiol. 2014 Mar;41(3):227-37. doi: 10.1111/1440-1681.12204.
PMID: 24471737 [PubMed - indexed for MEDLINE]

-- 2013 --

Soluble epoxide hydrolase inhibitor trans-4-[4-(3-adamantan-1-yl-ureido)-cyclohexyloxy]-benzoic acid is neuroprotective in rat model of ischemic stroke
Shaik JS, Ahmad M, Li W, Rose ME, Foley LM, Hitchens TK, Graham SH, Hwang SH, Hammock BD, Poloyac SM
Am J Physiol Heart Circ Physiol. 2013 Dec 1;305(11):H1605-13. doi: 10.1152/ajpheart.00471.2013. Epub 2013 Sep 16.
PMID: 24043255 [PubMed - indexed for MEDLINE]

Epoxy fatty acids and inhibition of the soluble epoxide hydrolase selectively modulate GABA mediated neurotransmission to delay onset of seizures
Inceoglu B, Zolkowska D, Yoo HJ, Wagner KM, Yang J, Hackett E, Hwang SH, Lee KS, Rogawski MA, Morisseau C, Hammock BD
PLoS One. 2013 Dec 11;8(12):e80922. doi: 10.1371/journal.pone.0080922. eCollection 2013.
PMID: 24349022 [PubMed - indexed for MEDLINE]

Development of a QPatch automated electrophysiology assay for identifying KCa3.1 inhibitors and activators
Jenkins DP, Yu W, Brown BM, Løjkner LD, Wulff H
Assay Drug Dev Technol. 2013 Nov-Dec;11(9-10):551-60. doi: 10.1089/adt.2013.543.
PMID: 24351043 [PubMed - indexed for MEDLINE]

Proconvulsant actions of intrahippocampal botulinum neurotoxin B in the rat
Bröer S, Zolkowska D, Gernert M, Rogawski MA
Neuroscience. 2013 Nov 12;252:253-61. doi: 10.1016/j.neuroscience.2013.07.050. Epub 2013 Jul 29.
PMID: 23906638 [PubMed - indexed for MEDLINE]

The therapeutic potential of small-conductance KCa2 channels in neurodegenerative and psychiatric diseases
Lam J, Coleman N, Garing AL, Wulff H
Expert Opin Ther Targets. 2013 Oct;17(10):1203-20. doi: 10.1517/14728222.2013.823161. Epub 2013 Jul 25. Review.
PMID: 23883298 [PubMed - indexed for MEDLINE]

Long-lasting attenuation of amygdala-kindled seizures after convection-enhanced delivery of botulinum neurotoxins a and B into the amygdala in rats
Gasior M, Tang R, Rogawski MA
J Pharmacol Exp Ther. 2013 Sep;346(3):528-34. doi: 10.1124/jpet.113.205070. Epub 2013 Jun 14.
PMID: 23772062 [PubMed - indexed for MEDLINE]

Isolation of alpaca anti-idiotypic heavy-chain single-domain antibody for the aflatoxin immunoassay
Wang Y, Li P, Majkova Z, Bever CR, Kim HJ, Zhang Q, Dechant JE, Gee SJ, Hammock BD
Anal Chem. 2013 Sep 3;85(17):8298-303. doi: 10.1021/ac4015885. Epub 2013 Aug 21.
PMID: 23965250 [PubMed - indexed for MEDLINE]

Neuroactive steroids for the treatment of status epilepticus
Rogawski MA, Loya CM, Reddy K, Zolkowska D, Lossin C
Epilepsia. 2013 Sep;54 Suppl 6:93-8. doi: 10.1111/epi.12289. Review.
PMID: 24001085 [PubMed - indexed for MEDLINE]

Epilepsy therapy development: technical and methodologic issues in studies with animal models
Galanopoulou AS, Kokaia M, Loeb JA, Nehlig A, Pitkänen A, Rogawski MA, Staley KJ, Whittemore VH, Dudek FE
Epilepsia. 2013 Aug;54 Suppl 4:13-23. doi: 10.1111/epi.12295. Review.
PMID: 23909850 [PubMed - indexed for MEDLINE]

Synthesis and biological evaluation of sorafenib- and regorafenib-like sEH inhibitors
Hwang SH, Wecksler AT, Zhang G, Morisseau C, Nguyen LV, Fu SH, Hammock BD
Bioorg Med Chem Lett. 2013 Jul 1;23(13):3732-7. doi: 10.1016/j.bmcl.2013.05.011. Epub 2013 May 15.
PMID: 23726028 [PubMed - indexed for MEDLINE]

Therapeutic activity of inhibition of the soluble epoxide hydrolase in a mouse model of scrapie
Poli G, Corda E, Martino PA, Dall'ara P, Bareggi SR, Bondiolotti G, Iulini B, Mazza M, Casalone C, Hwang SH, Hammock BD, Inceoglu B
Life Sci. 2013 Jun 21;92(23):1145-50. doi: 10.1016/j.lfs.2013.04.014. Epub 2013 May 5.
PMID: 23651659 [PubMed - indexed for MEDLINE]

Förster resonance energy transfer competitive displacement assay for human soluble epoxide hydrolase.
Lee KS, Morisseau C, Yang J, Wang P, Hwang SH, Hammock BD
Anal Biochem. 2013 Mar 15;434(2):259-68. doi: 10.1016/j.ab.2012.11.015. Epub 2012 Dec 5.
PMID: 23219719 [PubMed - indexed for MEDLINE]

Phage-displayed peptide that mimics aflatoxins and its application in immunoassay
Wang Y, Wang H, Li P, Zhang Q, Kim HJ, Gee SJ, Hammock BD
J Agric Food Chem. 2013 Mar 13;61(10):2426-33. doi: 10.1021/jf4004048. Epub 2013 Feb 27. Erratum in: J Agric Food Chem.
2013 Apr 24;61(16):3994.
PMID: 23394544 [PubMed - indexed for MEDLINE]

Rationally designed multitarget agents against inflammation and pain
Hwang SH, Wecksler AT, Wagner K, Hammock BD
Curr Med Chem. 2013;20(13):1783-99. Review.
PMID: 23410172 [PubMed - indexed for MEDLINE]

AMPA receptors as a molecular target in epilepsy therapy
Rogawski MA
Acta Neurol Scand Suppl. 2013;(197):9-18. doi: 10.1111/ane.12099. Review.
PMID: 23480151 [PubMed - indexed for MEDLINE]

Preclinical pharmacology of perampanel, a selective non-competitive AMPA receptor antagonist
Rogawski MA, Hanada T
Acta Neurol Scand Suppl. 2013;(197):19-24. doi: 10.1111/ane.12100. Review.
PMID: 23480152 [PubMed - indexed for MEDLINE]

-- 2012 --

Tetramethylenedisulfotetramine alters Ca²⁺ dynamics in cultured hippocampal neurons: mitigation by NMDA receptor blockade and GABA(A) receptor-positive modulation
Cao Z, Hammock BD, McCoy M, Rogawski MA, Lein PJ, Pessah IN
Toxicol Sci. 2012 Dec;130(2):362-72. doi: 10.1093/toxsci/kfs244. Epub 2012 Aug 13.
PMID: 22889812 [PubMed - indexed for MEDLINE]

Importance of membrane selection in the development of immunochromatographic assays for low-molecular weight compounds
Lee JY, Kim YA, Kim MY, Lee YT, Hammock BD, Lee HS
Anal Chim Acta. 2012 Dec 13;757:69-74. doi: 10.1016/j.aca.2012.10.052. Epub 2012 Nov 6.
PMID: 23206398 [PubMed - indexed for MEDLINE]

Neuregulin-1 is neuroprotective in a rat model of organophosphate-induced delayed neuronal injury
Li Y, Lein PJ, Liu C, Bruun DA, Giulivi C, Ford GD, Tewolde T, Ross-Inta C, Ford BD
Toxicol Appl Pharmacol. 2012 Jul 15;262(2):194-204. doi: 10.1016/j.taap.2012.05.001. Epub 2012 May 11.
PMID: 22583949 [PubMed - indexed for MEDLINE]

Spatiotemporal patterns of GFAP upregulation in rat brain following acute intoxication with diisopropylfluorophosphate (DFP)
Liu C, Li Y, Lein PJ, Ford BD
Curr Neurobiol. 2012 Jul;3(2):90-97.
PMID: 24039349 [PubMed]

Characterization of seizures induced by acute and repeated exposure to tetramethylenedisulfotetramine
Zolkowska D, Banks CN, Dhir A, Inceoglu B, Sanborn JR, McCoy MR, Bruun DA, Hammock BD, Lein PJ, Rogawski MA
J Pharmacol Exp Ther. 2012 May;341(2):435-46. doi: 10.1124/jpet.111.190579. Epub 2012 Feb 10.
PMID: 22328574 [PubMed - indexed for MEDLINE]